American Journal of Cardiology
Volume 100, Issue 2 , Pages 222-226 , 15 July 2007

Effects of Valsartan Alone Versus Valsartan/Simvastatin Combination on Ambulatory Blood Pressure, C-Reactive Protein, Lipoproteins, and Monocyte Chemoattractant Protein–1 in Patients With Hyperlipidemia and Hypertension

  • Sanjay Rajagopalan, MD

      Affiliations

    • Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio
    • Corresponding Author InformationCorresponding author: Tel: 641-247-2532; fax: 614-293-2561.
    • ,
  • Faiez Zannad, MD

      Affiliations

    • Hypertension and Preventive Cardiology Division, Department of Cardiovascular Disease, University of Nancy, Nancy, France
    • Dr. Zannad has received research grants/support from Pfizer, New York, New York; Servier, Neuilly-sur-Seine, France; and Bayer, Leverkusen, Germany; and honoraria from Guidant, Indianapolis, Indiana; and Servier, as well as served on the speakers’ bureaus for Pfizer, Servier, Novartis, Pharma, East Hanover, New Jersey; and Sankyo, Tokyo, Japan; and in a consultancy/advisory board capacity for Guidant.
    • ,
  • Anca Radauceanu, PhD

      Affiliations

    • Hypertension and Preventive Cardiology Division, Department of Cardiovascular Disease, University of Nancy, Nancy, France
    • ,
  • Robert Glazer, MD

      Affiliations

    • Novartis Pharmaceuticals Corporation, East Hanover, New Jersey
    • ,
  • Yan Jia, PhD

      Affiliations

    • Novartis Pharmaceuticals Corporation, East Hanover, New Jersey
    • ,
  • Margaret Forney Prescott, PhD

      Affiliations

    • Novartis Pharmaceuticals Corporation, East Hanover, New Jersey
    • ,
  • Mbabazi Kariisa, MPH

      Affiliations

    • Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio
    • ,
  • Bertram Pitt, MD

      Affiliations

    • Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan.
    • Dr. Pitt has received honoraria and served on the speakers’ bureau for Novartis, and acted in a consultancy/advisory board capacity for Novartis and Merck.

Received 8 November 2006 ,Revised 13 February 2007 ,Accepted 13 February 2007.

References 

  1. Glorioso N, Troffa C, Filigheddu F, Dettori F, Soro A, Parpaglia PP, et al. Effect of the HMG-CoA reductase inhibitors on blood pressure in patients with essential hypertension and primary hypercholesterolemia. Hypertension. 1999;34:1281–1286
  2. Borghi C, Veronesi M, Prandin MG, Dormi A, Ambrosioni E. Statins and blood pressure regulation. Curr Hypertens Rep. 2001;3:281–288
  3. Koh KK, Quon MJ, Han SH, Chung WJ, Ahn JY, Seo YH, et al. Additive beneficial effects of losartan combined with simvastatin in the treatment of hypercholesterolemic, hypertensive patients. Circulation. 2004;110:3687–3692
  4. Morawietz H, Erbs S, Holtz J, Schubert A, Krekler M, Goettsch W, et al. Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress: the EPAS trial. Circulation. 2006;114:I296–I301
  5. Jarai Z, Kapocsi J, Farsang C, Detki K, Pados G, Sebestyen Z, et al. Effect of fluvastatin on serum lipid levels in essential hypertension. Orv Hetil. 1996;137:1857–1859
  6. Ferrier KE, Muhlmann MH, Baguet JP, Cameron JD, Jennings GL, Dart AM, et al. Intensive cholesterol reduction lowers blood pressure and large artery stiffness in isolated systolic hypertension. J Am Coll Cardiol. 2002;39:1020–1025
  7. Blacher J, Protogerou AD, Safar ME. Large artery stiffness and antihypertensive agents. Curr Pharm Des. 2005;11:3317–3326
  8. Fliser D, Buchholz K, Haller H. Antiinflammatory effects of angiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammation. Circulation. 2004;110:1103–1107
  9. Willerson JT, Ridker PM. Inflammation as a cardiovascular risk factor. Circulation. 2004;109:II2–II10
  10. Ridker PM. High-sensitivity C-reactive protein and cardiovascular risk: rationale for screening and primary prevention. Am J Cardiol. 2003;92:17K–22K

PII: S0002-9149(07)00710-2

doi: 10.1016/j.amjcard.2007.02.085

American Journal of Cardiology
Volume 100, Issue 2 , Pages 222-226 , 15 July 2007

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