American Journal of Cardiology
Volume 99, Issue 9 , Pages 1246-1251 , 1 May 2007

Relation Between Soluble Intercellular Adhesion Molecule-1, Homocysteine, and Fibrinogen Levels and Race/Ethnicity in Women Without Cardiovascular Disease

  • Michelle A. Albert, MD, MPH

      Affiliations

    • Division of Cardiovascular Diseases, Donald W. Reynolds Center for Cardiovascular Disease Research, and Leducq Center for Cardiovascular Research, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
    • Division of Preventive Medicine, Donald W. Reynolds Center for Cardiovascular Disease Research, and Leducq Center for Cardiovascular Research, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts.
    • Dr. Albert is supported by an award from the Robert Wood Johnson Foundation, Princeton, New Jersey.
    • Drs. Albert and Ridker are supported by a grant from the Donald W. Reynolds Foundation, Las Vegas, Nevada.
    • Corresponding Author InformationCorresponding author: Tel.: 617-525-6858; fax: 617-582-6156.
    • ,
  • Robert J. Glynn, PhD

      Affiliations

    • Division of Preventive Medicine, Donald W. Reynolds Center for Cardiovascular Disease Research, and Leducq Center for Cardiovascular Research, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts.
    • ,
  • Julie E. Buring, ScD

      Affiliations

    • Division of Preventive Medicine, Donald W. Reynolds Center for Cardiovascular Disease Research, and Leducq Center for Cardiovascular Research, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts.
    • ,
  • Paul M. Ridker, MD, MPH

      Affiliations

    • Division of Cardiovascular Diseases, Donald W. Reynolds Center for Cardiovascular Disease Research, and Leducq Center for Cardiovascular Research, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
    • Division of Preventive Medicine, Donald W. Reynolds Center for Cardiovascular Disease Research, and Leducq Center for Cardiovascular Research, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts.
    • Drs. Albert and Ridker are supported by a grant from the Donald W. Reynolds Foundation, Las Vegas, Nevada.

Received 15 September 2006 ,Revised 7 December 2006 ,Accepted 7 December 2006.

References 

  1. Albert MA, Glynn RJ, Buring J, Ridker P. C-Reactive protein levels among women of various race/ethnic groups living in the United States. Am J Cardiol. 2004;93:1238–1242
  2. Khera A, McGuire DK, Murphy SA, Stanek HG, Das SR, Vongpatanasin W, et al. Race and gender differences in C-reactive protein levels. J Am Coll Cardiol. 2005;46:464–469
  3. Ridker PM, Cook NR, Lee IM, Gordon D, Gaziano JM, Manson JE, et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med. 2005;352:1293–3004
  4. Miller MA, Giuseppe A, Kerry SM, Strazzullo P, Cook DG, Cappuccio FP. Ethnic differences in circulating soluble adhesion molecules: the Wandsworth Heart and Stroke Study. Clin Sci. 2003;104:591–598
  5. Hwang SJ, Ballantyne CM, Sharrett AR, Smith LC, Davis CE, Gotto AM, et al. Circulating adhesion molecules VCAM-1, ICAM-1 and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) Study. Circulation. 1997;96:4219–4225
  6. Green D, Rulth KJ, Folsom AR, Liu K. Hemostatic factors in the Coronary Artery Risk Development In Young Adults (CARDIA) Study. Arterioscler Thromb. 1994;14:686–693
  7. Tracy RP, Bovill EG, Fried LP, Heiss G, Lee MH, Polak JF, et al. The distribution of coagulation factors VII and VIII and fibrinogen in adults over 65 years (Results from the Cardiovascular Health Study). Ann Epidemiol. 1992;2:509–519
  8. Nabulsi AA, Folsom AR, Heiss G, Weir SS, Chambless LE, Watson RL, et al. Fasting hyperinsulinemia and cardiovascular disease risk factors in non-diabetic adults: stronger associations in lean versus obese subjects (Atheroslerosis Risk in Communities Study Investigators). Metabolism. 1995;44:914–922
  9. Cook DG, Cappuccio FP, Atkinson RW, Wicks PD, Chitolie A, Nakandakare ER, et al. Ethnic differences in fibrinogen levels: the role of environmental factors and the beta-fibrinogen gene. Am J Epidemiol. 2001;153:799–806
  10. Iso H, Folsom AR, Sato S, Wu KK, Shimamoto T, Koike K, et al. Plasma fibrinogen and its correlates in Japanese and US population samples. Arterioscler Thromb. 1993;13:783–790
  11. Kain K, Blaxill JM, Catto AJ, Grant PJ, Carter AM. Increased fibrinogen levels among South Asians versus whites in the United Kingdom are not explained by common polymorphisms. Am J Epidemiol. 2002;156:174–179
  12. Kain K, Catto AJ, Grant PJ. Impaired fibrinolysis and increased fibrinogen levels in South Asian subjects. Atherosclerosis. 2001;156:457–461
  13. McKeigue PM, Marmot MG, Syndercombe Court YD, Cottier DE, Rahman S, Riemersma RA. Diabetes, hyperinsulinemia, and coronary risk factors in Bangladeshis in east London. Br Heart J. 1988;60:390–396
  14. Fischbacher C, Bopal R. Letter to the editor, re “Increased fibrinogen levels among South Asians versus whites in the United Kingdom are not explained by common polymorphisms” (letter). Am J Epidemiol. 2003;157:664–665
  15. Gangi V, Kafai MR. Demographic, health, lifestyle, and blood vitamin determinants of serum total homocysteine concentrations in the Third National Health and Nutrition Examination Survey, 1988–1994. Am J Clin Nutr. 2003;77:826–833
  16. Sacco RL, Anand K, Lee HS, Boden-Albala B, Stabler S, Allen R, et al. Homocysteine and the risk of ischemic stroke in a triethnic cohort: the Northern Manhattan Study. Stroke. 2004;35:2263–2269
  17. Cappuccio FP, Bell R, Perry IJ, Gilg J, Ueland PM, Refsum H, et al. Homocysteine levels in men and women of different ethnic and cultural background living in England. Atherosclerosis. 2002;164:95–102
  18. Annand S, Yusuf S, Vuksan V, Devanesen S, Teo KK, Montague PA, et al. Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE). Lancet. 2000;356:279–284
  19. Tanner MZ, Ozpolat E, Taskiran C, Onan MA, Gursel T, Karabulut E, et al. Effects of four different regiments of hormone replacement therapy on hemostatic parameters: a prospective randomized study. Maturitas. 2006;53:267–273
  20. Diaz AR, Melo RN, Gebara OC, D’Amico EA, Nussbacher A, Halbe HW, et al. Effects of conjugated equine estrogens or raloxifene on lipid profile, coagulation and fibrinolysis factors in postmenopausal women. Climacteric. 2005;8:63–70
  21. Zhang Y, Howard BV, Cowan LD, Welty TK, Schaefer CF, Wild RA, et al. Associations of postmenopausal hormone therapy with markers of hemostasis and inflammation and lipid profiles in diabetic and non-diabetic American Indian women: the Strong Heart Study. J Women Health. 2004;13:155–163
  22. Yilmazer M, Fenkei J, Fenkci S, Sonmezer M, Aktepe O, Altindis M, et al. Hormone replacement therapy, C-reactive protein and fibrinogen in healthy post-menopausal women. Maturitas. 2003;46:245–253
  23. Walsh BW, Kuller LH, Wild RA, Paul S, Farmer M, Lawrence JB, et al. Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women. JAMA. 1998;279:1445–1451
  24. Davison S, Davis SR. New markers for cardiovascular disease risk in women: impact of endogenous estrogen status and exogenous postmenopausal hormone therapy. Clin Endo Metab. 2003;88:2470–2478
  25. Gol M, Akan P, Dogan E, Karas C, Saygili U, Posaci C. Effects of estrogen, raloxifene and hormone replacement therapy on serum C-reactive protein and homocysteine levels. Maturitas. 2006;53:252–259

PII: S0002-9149(07)00152-X

doi: 10.1016/j.amjcard.2006.12.041

American Journal of Cardiology
Volume 99, Issue 9 , Pages 1246-1251 , 1 May 2007

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