American Journal of Cardiology
Volume 99, Issue 9 , Pages 1193-1195 , 1 May 2007

Prognostic Significance of Myocardial Ischemia During Dobutamine Stress Echocardiography in Asymptomatic Patients With Diabetes Mellitus and No Prior History of Coronary Events

  • Fabiola B. Sozzi, MD

      Affiliations

    • IRCCS Cardiology, Fondazione Ospedale Maggiore, Milan, Italy
    • Corresponding Author InformationCorresponding author: Tel: 39-329-566-2258; fax: 39-023-652-2640.
    • ,
  • Abdou Elhendy, MD

      Affiliations

    • Marshfield Clinic, Marshfield, Wisconsin
    • ,
  • Vittoria Rizzello, MD

      Affiliations

    • Thoraxcentre, Erasmus Medical Centre, Rotterdam, The Netherlands.
    • ,
  • Elena Biagini, MD

      Affiliations

    • Thoraxcentre, Erasmus Medical Centre, Rotterdam, The Netherlands.
    • ,
  • Ron T. van Domburg, PhD

      Affiliations

    • Thoraxcentre, Erasmus Medical Centre, Rotterdam, The Netherlands.
    • ,
  • Arend F.L. Schinkel, MD

      Affiliations

    • Thoraxcentre, Erasmus Medical Centre, Rotterdam, The Netherlands.
    • ,
  • Jeroen J. Bax, MD

      Affiliations

    • Thoraxcentre, Erasmus Medical Centre, Rotterdam, The Netherlands.
    • ,
  • Eleni Vourvouri, MD

      Affiliations

    • Thoraxcentre, Erasmus Medical Centre, Rotterdam, The Netherlands.
    • ,
  • Gian Battista Danzi, MD

      Affiliations

    • IRCCS Cardiology, Fondazione Ospedale Maggiore, Milan, Italy
    • ,
  • Don Poldermans, MD

      Affiliations

    • Thoraxcentre, Erasmus Medical Centre, Rotterdam, The Netherlands.

Received 14 September 2006 ,Revised 4 December 2006 ,Accepted 4 December 2006.

References 

  1. Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med. 1998;339:229–234
  2. Rutter MK, Wahid ST, McComb JM, Marshall SM. Significance of silent myocardial ischemia and microalbuminuria in predicting coronary events in asymptomatic patients with type 2 diabetes. J Am Coll Cardiol. 2002;40:56–61
  3. Wackers FJ, Young LH, Inzucchi SE, Chyun DA, Davey JA, Barrett EJ, et al Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study. Diabetes Care. 2004;27:1954–1961
  4. Sozzi FB, Elhendy A, Roelandt JR, van Domburg RT, Schinkel AF, Vourvouri EC, et al. Prognostic value of dobutamine stress echocardiography in patients with diabetes mellitus. Diabetes Care. 2003;26:1074–1078
  5. Chaowalit N, Arruda AL, McCully RB, Bailey KR, Pellikka PA. Dobutamine stress echocardiography in patients with diabetes mellitus. J Am Coll Cardiol. 2006;47:1029–1036
  6. National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 1979;28:1039–1057
  7. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997;20:1183–1197
  8. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, et al. Recommendations for quantification of the left ventricle by two-dimensional echocardiography: American Society of Echocardiography Committee on Standards, Subcommittee on Quantification of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr. 1989;2:358–367
  9. Poldermans D, Fioretti PM, Boersma E, Bax JJ, Thomson IR, Roelandt JR, et al. Long-term prognostic value of dobutamine-atropine stress echocardiography in 1737 patients with known or suspected coronary artery disease: a single-center experience. Circulation. 1999;99:757–762
  10. Elhendy A, Cornel JH, Roelandt JR, van Domburg RT, Nierop PR, Geleynse ML, et al. Relation between contractile response of akinetic segments during dobutamine stress echocardiography and myocardial ischemia assessed by simultaneous thallium-201 single-photon emission computed tomography. Am J Cardiol. 1996;77:955–959
  11. Scognamiglio R, Negut C, Ramondo A, Tiengo A, Avogaro A. Detection of coronary artery disease in asymptomatic patients with type 2 diabetes mellitus. J Am Coll Cardiol. 2006;47:65–71

PII: S0002-9149(07)00138-5

doi: 10.1016/j.amjcard.2006.12.027

American Journal of Cardiology
Volume 99, Issue 9 , Pages 1193-1195 , 1 May 2007

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