American Journal of Cardiology
Volume 99, Issue 6 , Pages 808-812 , 15 March 2007

Glutathione Peroxidase-1 Activity, Atherosclerotic Burden, and Cardiovascular Prognosis

  • Christine Espinola-Klein, MD

      Affiliations

    • Medical Department II, Johannes Gutenberg-University Mainz, Germany
    • Corresponding Author InformationCorresponding author: Tel.: 49-6131-172463; fax: 49-6131-176407.
    • ,
  • Hans J. Rupprecht, MD

      Affiliations

    • Medical Department II, Johannes Gutenberg-University Mainz, Germany
    • ,
  • Christoph Bickel, MD

      Affiliations

    • Department of Internal Medicine, Bundeswehrzentral Krankenhaus, Koblenz, Germany.
    • ,
  • Renate Schnabel, MD

      Affiliations

    • Medical Department II, Johannes Gutenberg-University Mainz, Germany
    • ,
  • Sabine Genth-Zotz, MD

      Affiliations

    • Medical Department II, Johannes Gutenberg-University Mainz, Germany
    • ,
  • Micheal Torzewski, MD

      Affiliations

    • Department of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg-University Mainz, Germany
    • ,
  • Karl Lackner, MD

      Affiliations

    • Department of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg-University Mainz, Germany
    • ,
  • Thomas Munzel, MD

      Affiliations

    • Medical Department II, Johannes Gutenberg-University Mainz, Germany
    • ,
  • Stefan Blankenberg, MD

      Affiliations

    • Medical Department II, Johannes Gutenberg-University Mainz, Germany
    • ,
  • AtheroGene Investigators

Received 31 August 2006 ,Revised 13 October 2006 ,Accepted 30 October 2006.

References 

  1. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999;340:115–126
  2. Glass CK, Witz JL. Atherosclerosis: the road ahead. Cell. 2001;104:503–516
  3. Steinberg D, Witztum JS. Is the oxidative modification hypothesis relevant to human atherosclerosis? (Do the antioxidant trials conducted to data refute the hypothesis?). Circulation. 2002;105:2107–2011
  4. Forsberg L, de Faire U, Morgenstern R. Oxidative stress, human genetic variation and disease. Arch Biochem Biophys. 2001;389:84–93
  5. Ursini F, Maiorino M, Brigelius-Flohe R, Aumann KD, Schomburg D, Flohe L. Diversity of glutathione peroxidases. Methods Enzymol. 1995;252:38–53
  6. Raes M, Michiels C, Remacle J. Comparative study of the enzymatic defense systems against oxygen-derived free radicals: the key role glutathione peroxidase. Free Radic Biol Med. 1987;3:3–7
  7. Arthur JR. The glutathione peroxidase. Cell Mol Life Sci. 2000;57:1825–1835
  8. Frank L, Massaro D. Oxygen toxicity. Am J Med. 1980;201:875–880
  9. Porter M, Pearson DJ, Suarezmendez VJ, Blann AD. Plasma, platelet and erythrocyte glutathione peroxidases as risk factors in ischemic heart disease in man. Clin Sci. 1992;83:343–352
  10. Candra M, Chandra N, Agrawal R, Kumar A, Ghatak A, Pandly VC. The free radical system in ischemic heart disease. Int J Cardiol. 1994;43:121–125
  11. Hill MF, Singal PK. Antioxidant and oxidative stress changes during failure subsequent to myocardial infarction in rats. Am J Pathol. 1996;148:291–300
  12. Forgione MA, Cap A, Liao R, Moldovan NI, Eberhardt RT, Lim CC, et al. Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure. Circulation. 2002;106:1154–1158
  13. Loeper J, Goy J, Rozensztazn L, Bedu O, Moisson P. Lipid peroxidation and protective enzymes during myocardial infarction. Clin Chim Acta. 1991;196:119–125
  14. Blankenberg S, Rupprecht HJ, Bickel C, Torzewski M, Hafner G, Tiret L, et al. Gluathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N Engl J Med. 2003;349:1603–1613
  15. Espinola-Klein C, Rupprecht HJ, Blankenberg S, Bickel C, Kopp H, Rippin G, et al. Impact of infectious burden on extent and long-term prognosis of atherosclerosis. Circulation. 2002;105:15–21
  16. Grobbe DE, Bots ML. Carotid artery intima-media thickness as an indicator of generalized atherosclerosis. J Intern Med. 1994;236:567–573
  17. Rupprecht HJ, Blankerberg S, Bickel C, Rippin G, Hafner G, Prellwitz W, et al. Impact of viral and bacterial infectious burden on long-term prognosis in patients with coronary artery disease. Circulation. 2001;104:25–31
  18. Arbeille P, Desombre C, Aesh B, Philippot M, Lapierre F. Quantification and assessment of carotid artery lesions: degree of stenosis and plaque volume. J Clin Ultrasound. 1995;23:113–124
  19. Newman AB, Shemanski L, Manolio TA, Cushman M, Mittelmark M, Polak JF, et al. Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. Arterioscler Thromb Vasc Biol. 1999;19:538–545
  20. Forgione MA, Weiss N, Heydrick CJ, Cap A, Klings ES, Bierl C, et al. Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2002;282:H1255–H1261
  21. Mehrabian M, Allayee H, Wong J, Shi W, Wang XP, Shaposhnik Z, et al. Identification of 5-lipoxigenase pathway as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res. 2002;91:120–126
  22. Lapenna D, de Gioia S, Ciofani G, Mezzetti A, Ucchino S, Calafiore AM, et al. Glutathione-related antioxidant defenses in human atherosclerotic plaques. Circulation. 1998;97:1930–1934

PII: S0002-9149(06)02372-1

doi: 10.1016/j.amjcard.2006.10.041

American Journal of Cardiology
Volume 99, Issue 6 , Pages 808-812 , 15 March 2007

Article Tools

* Image Usage & Resolution