American Journal of Cardiology
Volume 99, Issue 3 , Pages 369-373 , 1 February 2007

Relation of the “Hypertriglyceridemic Waist” Phenotype to Earlier Manifestations of Coronary Artery Disease in Patients With Glucose Intolerance and Type 2 Diabetes Mellitus

  • Julie St-Pierre, PhD

      Affiliations

    • Department of Medicine, Université de Montréal, University of Montreal Community Genomic Medicine Center and Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Québec, Canada
    • Québec Heart Institute, Laval Hospital Research Center, Sainte-Foy, Québec, Canada
    • Dr. St-Pierre is the recipient of the “Walter & Jessie Boyd & Charles Scriver” MD/PhD Studentship Award from the Canadian Institutes of Health Research (CIHR), Ottawa, Ontario, Canada; the Canadian Genetic Diseases Network, the Canadian Gene Cure Foundation, and Theratechnologies (A. Jean Degrandpré Scholarship Award).
  • ,
  • Isabelle Lemieux, PhD

      Affiliations

    • Québec Heart Institute, Laval Hospital Research Center, Sainte-Foy, Québec, Canada
  • ,
  • Patrice Perron, MSc, MD

      Affiliations

    • Department of Medicine, Université de Montréal, University of Montreal Community Genomic Medicine Center and Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Québec, Canada
    • Sherbrooke University Medical Center, Sherbrooke, Québec, Canada
  • ,
  • Diane Brisson, PhD

      Affiliations

    • Department of Medicine, Université de Montréal, University of Montreal Community Genomic Medicine Center and Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Québec, Canada
  • ,
  • Marta Santuré, PhD

      Affiliations

    • Department of Medicine, Université de Montréal, University of Montreal Community Genomic Medicine Center and Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Québec, Canada
  • ,
  • Marie-Claude Vohl, PhD

      Affiliations

    • Department of Food Sciences and Nutrition, Laval University, Sainte-Foy, Québec, Canada
    • Lipid Research Center, Laval University Medical Research Center, Sainte-Foy, Québec, Canada.
  • ,
  • Jean-Pierre Després, PhD

      Affiliations

    • Québec Heart Institute, Laval Hospital Research Center, Sainte-Foy, Québec, Canada
    • Department of Food Sciences and Nutrition, Laval University, Sainte-Foy, Québec, Canada
  • ,
  • Daniel Gaudet, MD, PhD

      Affiliations

    • Department of Medicine, Université de Montréal, University of Montreal Community Genomic Medicine Center and Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Québec, Canada
    • Dr. Gaudet was supported by the Canada Research Chair Program.
    • Corresponding Author InformationCorresponding author: Tel: 418-541-1077; fax: 418-541-1139.

Received 24 March 2006 ,Revised 22 August 2006 ,Accepted 22 August 2006.

References 

  1. Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP. The continuing epidemics of obesity and diabetes in the United States. JAMA. 2001;286:1195–1200
  2. Mokdad AH, Serdula MK, Dietz WH, Bowman BA, Marks JS, Koplan JP. The spread of the obesity epidemic in the United States, 1991–1998. JAMA. 1999;282:1519–1522
  3. Zimmet P, Shaw J, Murray S, Sicree R. The diabetes epidemic in full flight: forecasting the future. Diabetes Voice. 2003;48:12–16
  4. Grundy SM, Benjamin EJ, Burke GL, Chait A, Eckel RH, Howard BV, et al. Diabetes and cardiovascular disease (A statement for healthcare professionals from the American Heart Association). Circulation. 1999;100:1134–1146
  5. Lee WL, Cheung AM, Cape D, Zinman B. Impact of diabetes on coronary artery disease in women and men. Diabetes Care. 2000;23:962–968
  6. Qiao Q, Jousilahti P, Eriksson J, Tuomilehto J. Predictive properties of impaired glucose tolerance for cardiovascular risk are not explained by the development of overt diabetes during follow-up. Diabetes Care. 2003;26:2910–2914
  7. Lamarche B, Tchernof A, Mauriège P, Cantin B, Dagenais GR, Lupien PJ, et al. Fasting insulin and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart disease. JAMA. 1998;279:1955–1961
  8. Lemieux I, Pascot A, Couillard C, Lamarche B, Tchernof A, Alméras N, et al. Hypertriglyceridemic waist: a marker of the atherogenic metabolic triad (hyperinsulinemia, hyperapolipoprotein B, small, dense LDL) in men?. Circulation. 2000;102:179–184
  9. St-Pierre J, Lemieux I, Vohl MC, Perron P, Tremblay G, Després JP, et al. Contribution of abdominal obesity and hypertriglyceridemia to impaired fasting glucose and coronary artery disease. Am J Cardiol. 2002;90:15–18
  10. Gaudet D, Tremblay G, Perron P, Gagne C, Ouadahi Y, Moorjani S. Familial hypercholesterolemia in eastern Quebec: a public health problem? (The experience of the Hyperlipidemia Clinic of Chicoutimi). Union Med Can. 1995;124:54–60
  11. Richterich R, Dauwalder H. Zur Bestimmung der Plasmaglukosekonzentration mit der Hexokinase-Glucose-6-Phosphat-Dehydrogenase-Methode. Schweiz Med Wochenschr. 1971;101:615–618
  12. American Diabetes Association. Standards of medical care for patients with diabetes mellitus. Diabetes Care. 2003;26(suppl 1):S33–S50
  13. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined—a consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000;36:959–969
  14. Gaudet D, Vohl MC, Perron P, Tremblay G, Gagné C, Lesiège D, et al. Relationships of abdominal obesity and hyperinsulinemia to angiographically assessed coronary artery disease in men with known mutations in the LDL receptor gene. Circulation. 1998;97:871–877
  15. Gaudet D, Vohl MC, Julien P, Tremblay G, Perron P, Gagné C, et al. Relative contribution of low-density lipoprotein receptor and lipoprotein lipase gene mutations to angiographically assessed coronary artery disease among French Canadians. Am J Cardiol. 1998;82:299–305
  16. Burstein M, Samaille J. Sur un dosage rapide du cholestérol lié aux β-lipoprotéines du sérum. Clin Chim Acta. 1960;5:609
  17. Warnick GR, Benderson J, Albers JJ. Dextran sulfate-Mg2+ precipitation procedures for quantitation of high-density lipoprotein cholesterol. Clin Chem. 1982;28:1379–1387
  18. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
  19. Laurell CB. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Ann Biochem. 1966;15:45–52
  20. The Airlie (VA) Consensus Conference. In:  Lohman T,  Roche A,  Martorel R editor. Standardization of Anthropometric Measurements. Champaign, IL: Human Kinetics; 1988;p. 39–80
  21. NCEP Expert Panel. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2497
  22. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications (Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation). Diabet Med. 1998;15:539–553
  23. Snijder MB, Dekker JM, Visser M, Bouter LM, Stehouwer CD, Kostense PJ, et al. Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn study. Am J Clin Nutr. 2003;77:1192–1197
  24. Tchernof A, Lamarche B, Prud’homme D, Nadeau A, Moorjani S, Labrie F, et al. The dense LDL phenotype: association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men. Diabetes Care. 1996;19:629–637
  25. Lamarche B, Tchernof A, Moorjani S, Cantin B, Dagenais GR, Lupien PJ, et al. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men (Prospective results from the Québec Cardiovascular Study). Circulation. 1997;95:69–75
  26. Després JP, Lamarche B, Mauriège P, Cantin B, Dagenais GR, Moorjani S, et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med. 1996;334:952–957
  27. McNamara JR, Jenner JL, Li Z, Wilson PW, Schaefer EJ. Change in LDL particle size is associated with change in plasma triglyceride concentration. Arterioscler Thromb. 1992;12:1284–1290
  28. Laaksonen DE, Lakka HM, Niskanen LK, Kaplan GA, Salonen JT, Lakka TA. Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol. 2002;156:1070–1107
  29. Razak F, Anand S, Vuksan V, Davis B, Jacobs R, Teo KK, et al. Ethnic differences in the relationships between obesity and glucose-metabolic abnormalities: a cross-sectional population-based study. Int J Obes. 2005;29:656–667

PII: S0002-9149(06)02066-2

doi: 10.1016/j.amjcard.2006.08.041

American Journal of Cardiology
Volume 99, Issue 3 , Pages 369-373 , 1 February 2007