American Journal of Cardiology
Volume 98, Issue 5 , Pages 633-640 , 1 September 2006

A Meta-Analysis of the Effect of Soy Protein Supplementation on Serum Lipids

  • Kristi Reynolds, PhD, MPH

      Affiliations

    • Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA
    • Corresponding Author Information Corresponding author: Tel: 504-988-6972; fax: 504-988-1568.
    • ,
  • Ashley Chin, PhD, MPH, MA

      Affiliations

    • Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA
    • ,
  • Karen A. Lees, MPH

      Affiliations

    • Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA
    • ,
  • Aline Nguyen, MPH

      Affiliations

    • Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA
    • ,
  • Deborah Bujnowski, MPH

      Affiliations

    • Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA
    • ,
  • Jiang He, MD, PhD

      Affiliations

    • Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA
    • Department of Medicine, Tulane University School Medicine, New Orleans, Louisiana, USA

Received 7 February 2006 ,Revised 27 March 2006 ,Accepted 27 March 2006.

References 

  1. Goldberg AP , Lim A , Kolar JB , Grundhauser JJ , Steinke FH , Schonfeld G . Soybean protein independently lowers plasma cholesterol levels in primary hypercholesterolemia . Atherosclerosis . 1982;43:355–368
  2. Sacks FM , Breslow JL , Wood PG , Kass EH . Lack of an effect of dairy protein (casein) and soy protein on plasma cholesterol of strict vegetarians (an experiment and a critical review) . J Lipid Res . 1983;24:1012–1020
  3. Giovannetti PM . Constancy of fasting serum cholesterol of healthy young women upon substitution of soy protein isolate for meat and dairy protein in medium and low fat diets . Nutr Res . 1986;6:609–618
  4. Mercer NJH . Effects on human plasma lipids of substituting soybean protein isolate for milk protein in the diet . Nutr Reports Int . 1987;35:279–287
  5. Potter SM, Bakhit RM, Essex-Sorlie DL, Weingartner KE, Chapman KM, Nelson RA, et al. Depression of plasma cholesterol in men by consumption of baked products containing soy protein . Am J Clin Nutr . 1993;58:501–506
  6. Bakhit RM , Klein BP , Essex-Sorlie D , Ham JO , Erdman JW , Potter SM . Intake of 25 g of soybean protein with or without soybean fiber alters plasma lipids in men with elevated cholesterol concentrations . J Nutr . 1994;124:213–222
  7. Baum JA, Teng H, Erdman JW, Weigel RM, Klein BP, Persky VW, et al. Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women . Am J Clin Nutr . 1998;68:545–551
  8. Wong WW , Smith EO , Stuff JE , Hachey DL , Heird WC , Pownell HJ . Cholesterol-lowering effect of soy protein in normocholesterolemic and hypercholesterolemic men . Am J Clin Nutr . 1998;68:1385S–1389S
  9. Crouse JR , Morgan T , Terry JG , Ellis J , Vitolins M , Burke GL . A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins . Arch Intern Med . 1999;159:2070–2076
  10. Washburn S , Burke GL , Morgan T , Anthony M . Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women . Menopause . 1999;6:7–13
  11. Teixeira SR , Potter SM , Weigel R , Hannum S , Erdman JW , Hasler CM . Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men . Am J Clin Nutr . 2000;71:1077–1084
  12. Vigna GB, Pansini F, Bonaccorsi G, Albertazzi P, Donega P, Zanotti L, et al. Plasma lipoproteins in soy-treated postmenopausal women (a double-blind, placebo-controlled trial) . Nutr Metab Cardiovasc Dis . 2000;10:315–322
  13. Dent SB, Peterson CT, Brace LD, Swain JH, Reddy MB, Hanson KB, et al. Soy protein intake by perimenopausal women does not affect circulating lipids and lipoproteins or coagulation and fibrinolytic factors . J Nutr . 2001;131:2280–2287
  14. Gardner CD , Newell KA , Cherin R , Haskell WL . The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women . Am J Clin Nutr . 2001;73:728–735
  15. Hermansen K , Sondergaard M , Hoie L , Carstensen M , Brock B . Beneficial effects of a soy-based dietary supplement on lipid levels and cardiovascular risk markers in type 2 diabetic subjects . Diabetes Care . 2001;24:228–233
  16. Higashi K, Abata S, Iwamoto N, Ogura M, Yamashita T, Ishikawa O, et al. Effects of soy protein on levels of remnant-like particles cholesterol and vitamin E in healthy men . J Nutr Sci Vitaminol (Tokyo) . 2001;47:283–288
  17. Teede HJ , Dalais FS , Kotsopoulos D , Liang YL , Davis S , McGrath BP . Dietary soy has both beneficial and potentially adverse cardiovascular effects (a placebo-controlled study in men and postmenopausal women) . J Clin Endocrinol Metab . 2001;86:3053–3060
  18. Jayagopal V, Albertazzi P, Kilpatrick ES, Howarth EM, Jennings PE, Hepburn DA, et al. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes . Diabetes Care . 2002;25:1709–1714
  19. Lichtenstein AH, Jalbert SM, Adlercreutz H, Goldin BR, Rasmussen H, Schaefer EJ, et al. Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects . Arterioscler Thromb Vasc Biol . 2002;22:1852–1858
  20. Puska P , Korpelainen V , Hoie LH , Skovlund E , Lahti T , Smerud KT . Soy in hypercholesterolaemia (a double-blind, placebo-controlled trial) . Eur J Clin Nutr . 2002;56:352–357
  21. Tonstad S , Smerud K , Hoie L . A comparison of the effects of 2 doses of soy protein or casein on serum lipids, serum lipoproteins, and plasma total homocysteine in hypercholesterolemic subjects . Am J Clin Nutr . 2002;76:78–84
  22. Blum A, Lang N, Vigder F, Israeli P, Gumanovsky M, Lupovitz S, et al. Effects of soy protein on endothelium-dependent vasodilatation and lipid profile in postmenopausal women with mild hypercholesterolemia . Clin Invest Med . 2003;26:20–26
  23. Cuevas AM , Irribarra VL , Castillo OA , Yanez MD , Germain AM . Isolated soy protein improves endothelial function in postmenopausal hypercholesterolemic women . Eur J Clin Nutr . 2003;57:889–894
  24. Steinberg FM , Guthrie NL , Villablanca AC , Kumar K , Murray MJ . Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women . Am J Clin Nutr . 2003;78:123–130
  25. Greany KA , Nettleton JA , Wangen KE , Thomas W , Kurzer MS . Probiotic consumption does not enhance the cholesterol-lowering effect of soy in postmenopausal women . J Nutr . 2004;134:3277–3283
  26. Kreijkamp-Kaspers S, Kok L, Grobbee DE, de Haan EH, Aleman A, Lampe JW, et al. Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women (a randomized controlled trial) . JAMA . 2004;292:65–74
  27. Teixeira SR, Tappenden KA, Carson L, Jones R, Prabhudesai M, Marshall WP, et al. Isolated soy protein consumption reduces urinary albumin excretion and improves the serum lipid profile in men with type 2 diabetes mellitus and nephropathy . J Nutr . 2004;134:1874–1880
  28. Rice JA . Mathematical Statistics and Data Analysis . Belmont, MA: Duxbury Press; 1988;
  29. Follmann D , Elliott P , Suh I , Cutler J . Variance imputation for overviews of clinical trials with continuous response . J Clin Epidemiol . 1992;45:769–773
  30. DerSimonian R , Laird N . Meta-analysis in clinical trials . Control Clin Trials . 1986;7:177–188
  31. Begg CB . Publication bias . In:  Cooper H ,  Hedges LV editor. The Handbook of Research Synthesis . New York: Russell Sage Foundation; 1994;p. 399–409
  32. Anderson JW , Johnstone BM , Cook-Newell ME . Meta-analysis of the effects of soy protein intake on serum lipids . N Engl J Med . 1995;333:276–282
  33. Erdman JW  AHA Science Advisory . Soy protein and cardiovascular disease (a statement for healthcare professionals from the Nutrition Committee of the AHA) . Circulation . 2000;102:2555–2559
  34. Krauss RM, Eckel RH, Howard B, Appel LJ, Daniels SR, Deckelbaum RJ, et al  AHA Dietary Guidelines, revision 2000 (a statement for healthcare professionals from the Nutrition Committee of the American Heart Association) . Circulation . 2000;102:2284–2299

 This study was partially supported by a grant (R01 HL68057) from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland. Dr. Reynolds was supported by the Building Interdisciplinary Research Careers in Women’s Health Scholarship (Grant K12 HD43451) from the National Institutes of Health, Bethesda, Maryland.

PII: S0002-9149(06)00991-X

doi: 10.1016/j.amjcard.2006.03.042

American Journal of Cardiology
Volume 98, Issue 5 , Pages 633-640 , 1 September 2006

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