American Journal of Cardiology
Volume 97, Issue 3 , Pages 409-411 , 1 February 2006

Comparison of the Efficacy and Safety Profiles of Intravenous Vitamin K and Fresh Frozen Plasma as Treatment of Warfarin-Related Over-Anticoagulation in Patients With Mechanical Heart Valves

  • Kai-Hang Yiu, MBBS

      Affiliations

    • Cardiology Division, Department of Medicine, Queen Mary Hospital, Hong Kong, China
    • ,
  • Chung-Wah Siu, MBBS

      Affiliations

    • Cardiology Division, Department of Medicine, Queen Mary Hospital, Hong Kong, China
    • ,
  • Man-Hong Jim, MBBS

      Affiliations

    • Cardiac and Medical Unit, The Grantham Hospital, Hong Kong, China
    • ,
  • Hung-Fat Tse, MD

      Affiliations

    • Cardiology Division, Department of Medicine, Queen Mary Hospital, Hong Kong, China
    • ,
  • Katherine Fan, MBBS

      Affiliations

    • Cardiac and Medical Unit, The Grantham Hospital, Hong Kong, China
    • ,
  • Mo-Chee Chau, MBBS

      Affiliations

    • Cardiac and Medical Unit, The Grantham Hospital, Hong Kong, China
    • ,
  • Wing Hing Chow, MBBS

      Affiliations

    • Cardiac and Medical Unit, The Grantham Hospital, Hong Kong, China
    • Corresponding Author InformationCorresponding author: Tel: 852-2518-2618; fax: 852-2518-8558.

Received 15 July 2005 ,Revised 22 August 2005 ,Accepted 22 August 2005.

References 

  1. Palareti G, Leali N, Coccheri S, Poggi M, Manotti C, D’Angelo A, et al  Bleeding complications of oral anticoagulant treatment (an inception-cohort, prospective collaborative study (ISCOAT)) . Lancet . 1996;348:423–428
  2. Bonow RO, Carabello B, DeLeon AC, Edmunds LH, Fedderly BJ, Freed MD, et al. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines . J Am Coll Cardiol . 1998;32:1486–1588
  3. Shetty HGM , Backhouse G , Bentley DP , Routledge PA . Effective reversal of warfarin-induced excessive anticoagulation with low dose Vitamin K1 . Thromb Haemost . 1992;67:13–15
  4. Shields RC , McBane RD , Kuiper JD , Li H , Heit JA . Efficacy and safety of intravenous phytonadione (Vitamin K1) in patients on long-term oral anticoagulant therapy . Mayo Clin Proc . 2001;76:260–266

PII: S0002-9149(05)01832-1

doi: 10.1016/j.amjcard.2005.08.062

American Journal of Cardiology
Volume 97, Issue 3 , Pages 409-411 , 1 February 2006

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