American Journal of Cardiology
Volume 96, Issue 11 , Pages 1491-1493 , 1 December 2005

Effect of Statin Use in Patients With Acute Coronary Syndromes and a Serum Low-Density Lipoprotein ≤80 mg/dl

  • Thomas T. Tsai, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
    • Corresponding Author InformationCorresponding author: Tel: 734-998-4967; fax: 734-998-9939.
    • ,
  • Brahmajee K. Nallamothu, MD, MPH

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
    • Health Services Research and Development Center of Excellence, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan.
    • ,
  • Debabrata Mukherjee, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
    • ,
  • Melvyn Rubenfire, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
    • ,
  • Jianming Fang, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
    • ,
  • Paul Chan, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
    • Health Services Research and Development Center of Excellence, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan.
    • ,
  • Eva Kline-Rogers, RN

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
    • ,
  • Amisha Patel, BS

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
    • ,
  • David F. Armstrong, BS

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
    • ,
  • Kim A. Eagle, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
    • ,
  • A.D. Goldberg, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.

Received 13 April 2005 ,Revised 8 July 2005 ,Accepted 8 July 2005.

References 

  1. Mukherjee D , Fang J , Chetcuti S , Moscucci M , Kline-Rogers E , Eagle KA . Impact of combination evidence-based medical therapy on mortality in patients with acute coronary syndromes . Circulation . 2004;109:745–749
  2. Cannon CP, Braunwald E, McCabe CH, Rader DJ, Rouleau JL, Belder R, et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes . N Engl J Med . 2004;350:1495–1504
  3. Schwartz GG, Olsson AG, Ezekowitz MD, Ganz P, Oliver MF, Waters D, et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial . JAMA . 2001;285:1711–1718
  4. Schatz IJ , Masaki K , Yano K , Chen R , Rodriguez BL , Curb JD . Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program (a cohort study) . Lancet . 2001;358:351–355
  5. Dyker AG , Weir CJ , Lees KR . Influence of cholesterol on survival after stroke (retrospective study) . BMJ . 1997;314:1584–1588
  6. Horwich TB , Hamilton MA , Maclellan WR , Fonarow GC . Low serum total cholesterol is associated with marked increase in mortality in advanced heart failure . J Card Fail . 2002;8:216–224
  7. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals (a randomised placebo-controlled trial) . Lancet . 2002;360:7–22
  8. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group . Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels . N Engl J Med . 1998;339:1349–1357
  9. LaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart JC, et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease . N Engl J Med . 2005;352:1425–1435

 Dr. Tsai is supported by training grant 5T32HL007853-08 and Dr. Nallamothu is supported by K12 grant RR017607-01 from the National Institutes of Health, Bethesda, Maryland.

PII: S0002-9149(05)01452-9

doi: 10.1016/j.amjcard.2005.07.069

American Journal of Cardiology
Volume 96, Issue 11 , Pages 1491-1493 , 1 December 2005

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