American Journal of Cardiology
Volume 96, Issue 11 , Pages 1484-1490 , 1 December 2005

Relation of High-Sensitivity C-Reactive Protein Level With Coronary Vasospastic Angina Pectoris in Patients Without Hemodynamically Significant Coronary Artery Disease

  • Ming-Jui Hung, MD

      Affiliations

    • Cardiology Section, Department of Medicine, Chang Gung Memorial Hospital at Keelung, Taoyuan, Taiwan.
    • Graduate Institute of Clinical Medical Sciences, Chang Gung University Medical College, Taoyuan, Taiwan.
    • ,
  • Wen-Jin Cherng, MD

      Affiliations

    • Cardiology Section, Department of Medicine, Chang Gung Memorial Hospital at Keelung, Taoyuan, Taiwan.
    • Corresponding Author InformationCorresponding author: Tel: 886-2-2431-3131, ext 2628; fax: 886-2-2433-5342.
    • ,
  • Ning-I. Yang, MB, ChB

      Affiliations

    • Cardiology Section, Department of Medicine, Chang Gung Memorial Hospital at Keelung, Taoyuan, Taiwan.
    • ,
  • Chi-Wen Cheng, MD

      Affiliations

    • Cardiology Section, Department of Medicine, Chang Gung Memorial Hospital at Keelung, Taoyuan, Taiwan.
    • ,
  • Li-Fu Li, MD

      Affiliations

    • Graduate Institute of Clinical Medical Sciences, Chang Gung University Medical College, Taoyuan, Taiwan.

Received 3 May 2005 ,Revised 7 July 2005 ,Accepted 7 July 2005.

References 

  1. Hung MJ , Cherng WJ , Cheng CW , Yang NI . Effect of anti-spastic agents (calcium antagonists and/or isosorbide dinitrate) on high-sensitivity C-reactive protein in patients with coronary vasospastic angina pectoris and no hemodynamically significant coronary artery disease . Am J Cardiol . 2005;95:84–87
  2. Miyao Y, Kugiyama K, Kawano H, Motoyama T, Ogawa H, Yoshimura M, et al. Diffuse intimal thickening of coronary arteries in patients with coronary spastic angina . J Am Coll Cardiol . 2000;36:432–437
  3. Suzuki H, Kawai S, Aizawa T, Kato K, Sunayama S, Okada R, et al. Histological evaluation of coronary plaque in patients with variant angina (relationship between vasospasm and neointimal hyperplasia in primary coronary lesions) . J Am Coll Cardiol . 1999;33:198–205
  4. Roberts WC, Curry RC, Isner JM, Waller BF, McManus BM, Mariani-Constantini R, et al. Sudden death in Prinzmetal’s angina with coronary spasm documented by angiography. Analysis of three necropsy patients . Am J Cardiol . 1982;50:203–210
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  8. Kugiyama K, Ohgushi M, Motoyama T, Sugiyama S, Ogawa H, Yoshimura M, et al. Nitric oxide-mediated flow-dependent dilation is impaired in coronary arteries in patients with coronary spastic angina . J Am Coll Cardiol . 1997;30:920–926
  9. Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Kugiyama K, Ogawa H, et al. T−786→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm . Circulation . 1999;99:2864–2870
  10. Widlansky ME , Gokce N , Keaney JF , Vita JA . The clinical implications of endothelial dysfunction . J Am Coll Cardiol . 2003;42:1149–1160
  11. Verma S , Buchanan MR , Anderson TJ . Endothelial function testing as a biomarker of vascular disease . Circulation . 2003;108:2054–2059
  12. Zeiher AM , Drexler H , Wollschläger H , Just H . Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis . Circulation . 1991;83:391–401
  13. Hung MJ , Kuo LT , Cheng CW , Chang CB , Cherng WJ . Comparison of peripheral monocyte counts in patients with and without coronary spasm and without coronary narrowing . Am J Cardiol . 2004;93:620–624
  14. Terashima M, Akita H, Kanazawa K, Shiga N, Matsuda Y, Hirata KI, et al. Circulating T-lymphocyte activation in patients with variant angina . Coron Artery Dis . 2000;13:161–168

PII: S0002-9149(05)01432-3

doi: 10.1016/j.amjcard.2005.07.055

American Journal of Cardiology
Volume 96, Issue 11 , Pages 1484-1490 , 1 December 2005

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