American Journal of Cardiology
Volume 96, Issue 10 , Pages 1361-1364 , 15 November 2005

Effect of Intensive Versus Moderate Lipid Lowering on Endothelial Function and Vascular Responsiveness to Angiotensin II in Stable Coronary Artery Disease

  • Pim van der Harst, MD

      Affiliations

    • Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • Corresponding Author InformationCorresponding author: Tel: 31-50-361-2810; fax: 31-50-363-2812.
    • ,
  • Lodewijk J. Wagenaar, MD, PhD

      Affiliations

    • Department of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands
    • ,
  • Hendrik Buikema, PhD

      Affiliations

    • Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Adriaan A. Voors, MD, PhD

      Affiliations

    • Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • H.W. Thijs Plokker, MD, PhD

      Affiliations

    • Department of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands
    • ,
  • Wim J. Morshuis, MD, PhD

      Affiliations

    • Department of Thorax Surgery, St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands
    • ,
  • A. Jacob Six, MD, PhD

      Affiliations

    • Department of Cardiology, Hofpoort Hospital, Woerden, The Netherlands
    • ,
  • Piet W. Boonstra, MD, PhD

      Affiliations

    • Department of Cardiothorax Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Georg Nickenig, MD

      Affiliations

    • Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, Homburg, Germany.
    • ,
  • Sven Wassmann, MD

      Affiliations

    • Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, Homburg, Germany.
    • ,
  • Dirk J. van Veldhuisen, MD, PhD

      Affiliations

    • Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Wiek H. van Gilst, PhD

      Affiliations

    • Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Received 11 May 2005 ,Revised 7 July 2005 ,Accepted 7 July 2005.

References 

  1. LaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart JC, et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease . N Engl J Med . 2005;352:1425–1435
  2. Treasure CB, Klein JL, Weintraub WS, Talley JD, Stillabower ME, Kosinski AS, et al. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease . N Engl J Med . 1995;332:481–487
  3. Nickenig G , Sachinidis A , Michaelsen F , Bohm M , Seewald S , Vetter H . Upregulation of vascular angiotensin II receptor gene expression by low-density lipoprotein in vascular smooth muscle cells . Circulation . 1997;95:473–478
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  5. Oosterga M, Voors AA, Buikema H, Pinto YM, Haber HE, Ebels T, et al. Angiotensin II formation in human vasculature after chronic ACE inhibition (a prospective, randomized, placebo-controlled study) . Cardiovasc Drugs Ther . 2000;14:55–60
  6. Buikema H , Grandjean JG , van den Broek S , van Gilst WH , Lie KI , Wesseling H . Differences in vasomotor control between human gastroepiploic and left internal mammary artery . Circulation . 1992;86:II205–II209
  7. Feelisch M . The biochemical pathways of nitric-oxide formation from nitrovasodilators—appropriate choice of exogenous no donors and aspects of preparation and handling of aqueous no solutions . J Cardiovasc Pharmacol . 1991;17:S25–S33
  8. Laufs U , La FV , Plutzky J , Liao JK . Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors . Circulation . 1998;97:1129–1135
  9. Hernandez-Perera O, Perez-Sala D, Navarro-Antolin J, Sanchez-Pascuala R, Hernandez G, Diaz C, et al. Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells . J Clin Invest . 1998;101:2711–2719
  10. Vita JA, Treasure CB, Nabel EG, McLenachan JM, Fish RD, Yeung AC, et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease . Circulation . 1990;81:491–497
  11. Asselbergs FW , van der Harst P , Jessurun GA , Tio RA , van Gilst WH . Clinical impact of vasomotor function assessment and the role of ACE-inhibitors and statins . Vasc Pharmacol . 2005;42:125–140
  12. Yan C , Kim D , Aizawa T , Berk BC . Functional interplay between angiotensin II and nitric oxide (cyclic GMP as a key mediator) . Arterioscler Thromb Vasc Biol . 2003;23:26–36

 This study was supported in part by a grand from Pfizer, Cappelle a/d IJssel, The Netherlands; Dr. van der Harst is supported by ZON-MW (920-03-236) of The Netherlands Organisation for Health Research and Development, The Netherlands; and Dr. van Veldhuisen received Grant D97-017 from the Netherlands Heart Foundation, The Netherlands.

PII: S0002-9149(05)01357-3

doi: 10.1016/j.amjcard.2005.07.052

American Journal of Cardiology
Volume 96, Issue 10 , Pages 1361-1364 , 15 November 2005

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