American Journal of Cardiology
Volume 96, Issue 6 , Pages 810-814 , 15 September 2005

Effects of Pomegranate Juice Consumption on Myocardial Perfusion in Patients With Coronary Heart Disease

  • Michael D. Sumner, PhD

      Affiliations

    • The Preventive Medicine Research Institute, Sausalito, California
    • ,
  • Melanie Elliott-Eller, RN, MSN

      Affiliations

    • The Preventive Medicine Research Institute, Sausalito, California
    • ,
  • Gerdi Weidner, PhD

      Affiliations

    • The Preventive Medicine Research Institute, Sausalito, California
    • ,
  • Jennifer J. Daubenmier, PhD

      Affiliations

    • The Preventive Medicine Research Institute, Sausalito, California
    • ,
  • Mailine H. Chew, MD

      Affiliations

    • California Pacific Medical Center, San Francisco, California
    • ,
  • Ruth Marlin, MD

      Affiliations

    • The Preventive Medicine Research Institute, Sausalito, California
    • ,
  • Caren J. Raisin, RN

      Affiliations

    • The Preventive Medicine Research Institute, Sausalito, California
    • ,
  • Dean Ornish, MD

      Affiliations

    • The Preventive Medicine Research Institute, Sausalito, California
    • California Pacific Medical Center, San Francisco, California
    • School of Medicine, University of California, San Francisco, San Francisco, California
    • Corresponding Author InformationCorresponding author: Tel: 415-332-2525, ext 222; fax: 415-332-2588.

Received 28 December 2004 ,Revised 11 May 2005 ,Accepted 11 May 2005.

References 

  1. Aviram M, Dornfeld L, Rosenblat M, Volkova N, Kaplan M, Coleman R, et al. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation (studies in humans and in atherosclerotic apolipoprotein E-deficient mice) . Am J Clin Nutr . 2000;71:1062–1076
  2. Gil MI , Tomas-Barberan FA , Hess-Pierce B , Holcroft DM , Kader AA . Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing . J Agric Food Chem . 2000;48:4581–4589
  3. Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation . Clin Nutr . 2004;23:423–433
  4. Sharir T, Germano G, Kang X, Lewin HC, Miranda R, Cohen I, et al. Prediction of myocardial infarction versus cardiac death by gated myocardial perfusion SPECT (risk stratification by the amount of stress-induced ischemia and the poststress ejection fraction) . J Nucl Med . 2001;42:831–837
  5. Aviram M . Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases . Free Radic Res . 2000;33:S85–S97
  6. Aviram M , Fuhrman B . Flavonoid antioxidants protect LDL from oxidation and attenuate atherosclerosis . Curr Opin Lipidol . 2001;12:41–48
  7. Aviram M, Dornfeld L, Kaplan M, Coleman R, Gaitini D, Nitecki S, et al  Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases (studies in atherosclerotic mice and in humans) . Drugs Exp Clin Res . 2002;28:49–62
  8. Aviram M . Pomegranate juice as a major source for polyphenolic flavonoids and it is most potent antioxidant against LDL oxidation and atherosclerosis . Free Radic Res . 2002;36:S71–S73
  9. Freedman JE, Parker C, Li L, Perlman JA, Frei B, Ivanov V, et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release . Circulation . 2001;103:2792–2798
  10. Caimi G , Carollo C , Lo Presti R . Wine and endothelial function . Drugs Exp Clin Res . 2003;29:235–242

 This study was supported by a grant from the Resnick Foundation, Los Angeles, California, to the Preventive Medicine Research Institute, which also provided the pomegranate juice. The foundation did not participate in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the report.

PII: S0002-9149(05)01027-1

doi: 10.1016/j.amjcard.2005.05.026

American Journal of Cardiology
Volume 96, Issue 6 , Pages 810-814 , 15 September 2005

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