American Journal of Cardiology
Volume 95, Issue 6 , Pages 709-715 , 15 March 2005

Impact of obesity on revascularization and restenosis rates after bare-metal and drug-eluting stent implantation (from the TAXUS-IV trial)

  • Eugenia Nikolsky, MD, PhD

      Affiliations

    • Cardiovascular Research Foundation, New York, New York
    • ,
  • Edward Kosinski, MD

      Affiliations

    • Connecticut Clinical Research, Bridgeport, Connecticut
    • ,
  • Gregory J. Mishkel, MD

      Affiliations

    • St. Johns Hospital, Springfield, Illinois
    • ,
  • Carey Kimmelstiel, MD

      Affiliations

    • New England Medical Center, Boston, Massachusetts
    • ,
  • Thomas F. McGarry Jr., MD

      Affiliations

    • Mercy Health Center, Oklahoma City, Oklahoma
    • ,
  • Roxana Mehran, MD

      Affiliations

    • Cardiovascular Research Foundation, New York, New York
    • ,
  • Martin B. Leon, MD

      Affiliations

    • Cardiovascular Research Foundation, New York, New York
    • ,
  • Mary E. Russell, MD

      Affiliations

    • Boston Scientific Corp, Natick, Massachusetts
    • ,
  • Stephen G. Ellis, MD

      Affiliations

    • Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • Gregg W. Stone, MD

      Affiliations

    • Cardiovascular Research Foundation, New York, New York
    • Corresponding Author InformationAddress for reprints: Gregg W. Stone, MD, Cardiovascular Research Foundation, 55 East 59th Street, 6th Floor, New York, New York 10022

Received 28 October 2004 ,Accepted 17 November 2005.

References 

  1. Calle EE , Thun MJ , Petrelli JM , Rodriguez C , Heath CW . Body-mass index and mortality in a prospective cohort of U.S. adults . N Engl J Med . 1999;341:1097–1105
  2. Flegal KM , Carroll MD , Ogden CL , Johnson CL . Prevalence and trends in obesity among US adults, 1999–2000 . JAMA . 2002;288:1723–1727
  3. Wilson PW , D'Agostino RB , Sullivan L , Parise H , Kannel WB . Overweight and obesity as determinants of cardiovascular risk: the Framingham experience . Arch Intern Med . 2002;162:1867–1872
  4. Gruberg L, Weissman NJ, Waksman R, Fuchs S, Deible R, Pinnow EE, et al  The impact of obesity on the short-term and long-term outcomes after percutaneous coronary intervention: the obesity paradox? . J Am Coll Cardiol . 2002;39:578–584
  5. Gurm HS , Brennan DM , Booth J , Tcheng JE , Lincoff AM , Topol EJ . Impact of body mass index on outcome after percutaneous coronary intervention (the obesity paradox) . Am J Cardiol . 2002;90:42–45
  6. Powell BD, Lennon RJ, Lerman A, Bell MR, Berger PB, Higano ST, et al. Association of body mass index with outcome after percutaneous coronary intervention . Am J Cardiol . 2003;91:472–476
  7. Stone GW, Ellis SG, Cox DA, Hermiller J, O'Shaughnessy C, Mann JT, et al  A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease . N Engl J Med . 2004;350:221–231
  8. St Jeor ST, Brownell KD, Atkinson RL, Bouchard C, Dwyer J, Foreyt JP, et al. Obesity (Workshop III. AHA Prevention Conference III. Behavior change and compliance: keys to improving cardiovascular health) . Circulation . 1993;88:1391–1396
  9. de Ferranti SD , Gauvreau K , Ludwig DS , Neufeld EJ , Newburger JW , Rifai N . Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey . Circulation . 2004;110:2494–2497
  10. Takagi T, Yoshida K, Akasaka T, Kaji S, Kawamoto T, Honda Y, et al. Hyperinsulinemia during oral glucose tolerance test is associated with increased neointimal tissue proliferation after coronary stent implantation in nondiabetic patients: a serial intravascular ultrasound study . J Am Coll Cardiol . 2000;36:731–738
  11. Piatti P, Di Mario C, Monti LD, Fragasso G, Sgura F, Caumo A, et al  Association of insulin resistance, hyperleptinemia, and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting . Circulation . 2003;108:2074–2081
  12. Minutello RM, Chou ET, Hong MK, Bergman G, Parikh M, Iacovone F, et al. Impact of body mass index on in-hospital outcomes following percutaneous coronary intervention (report from the New York State Angioplasty Registry) . Am J Cardiol . 2004;93:1229–1232

PII: S0002-9149(04)01873-9

doi: 10.1016/j.amjcard.2004.11.020

American Journal of Cardiology
Volume 95, Issue 6 , Pages 709-715 , 15 March 2005

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