Effects of atorvastatin (10 mg) on hemostatic and inflammatory parameters in hyperlipidemic patients with angiographically proven coronary artery disease

Tekin, Abdullah; Tekin, Göknur; Güzelsoy, Deniz; Kaya, Ayşem; Gürel, Çiğdem Vural; Yiğit, Zerrin; Ulutin, Turgut

doi:10.1016/j.amjcard.2004.03.065

« Previous Next »American Journal of Cardiology
Volume 94, Issue 2 , Pages 206-209, 15 July 2004

Effects of atorvastatin (10 mg) on hemostatic and inflammatory parameters in hyperlipidemic patients with angiographically proven coronary artery disease☆

Abdullah Tekin, MD
- Department of Cardiology, Faculty of Medicine, Başkent University, Adana, Turkey
- Dr. Tekin's address is: Başkent University, Faculty of Medicine, Department of Cardiology, Dadaloğlu Mahallesi, 39. Sok. No. 6, 01250 Yureğir/Adana, Turkey.
Göknur Tekin, MD
- Department of Cardiology, Faculty of Medicine, Başkent University, Adana, Turkey
Deniz Güzelsoy, MD
- Institute of Cardiology, Department of Cardiology, İstanbul University, İstanbul, Turkey
Ayşem Kaya, PhD
- Department of Biochemistry, İstanbul, Turkey
Çiğdem Vural Gürel, PhD
- Department of Medical Biology, Cerrahpaşa Medical Faculty, İstanbul University, İstanbul, Turkey
Zerrin Yiğit, MD
- Institute of Cardiology, Department of Cardiology, İstanbul University, İstanbul, Turkey
Turgut Ulutin, PhD
- Department of Medical Biology, Cerrahpaşa Medical Faculty, İstanbul University, İstanbul, Turkey

Received 22 December 2003; received in revised form 25 March 2004; accepted 25 March 2004.

Abstract

Hyperlipidemic patients with coronary heart disease were treated with atorvastatin, and its effects on hemostatic and inflammatory parameters were assessed. After 3 months of therapy, the plasma levels of plasminogen activator inhibitor, prothrombin fragment 1+2, highly sensitive C-reactive protein, von Willebrand factor, and fibrinogen were significantly reduced; no significant reductions were observed in lipoprotein(a) and tissue plasminogen activator antigen levels.