American Journal of Cardiology
Volume 93, Issue 1 , Pages 18-23 , 1 January 2004

Correlation of postpercutaneous coronary intervention creatine kinase-MB and troponin I elevation in predicting mid-term mortality

  • Annapoorna S Kini, MD, MRCP

      Affiliations

    • Cardiac Catheterization Laboratory, Cardiovascular Institute, Mount Sinai Hospital, New York, New York, USA
    • ,
  • Paul Lee, MD

      Affiliations

    • University of Toronto, Toronto, Ontario, Canada
    • ,
  • Jonathan D Marmur, MD

      Affiliations

    • Cardiac Catheterization Laboratory, Cardiovascular Institute, Mount Sinai Hospital, New York, New York, USA
    • Department of Medicine, Division of Cardiology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York, USA
    • ,
  • Ajay Agarwal, MD

      Affiliations

    • Cardiac Catheterization Laboratory, Cardiovascular Institute, Mount Sinai Hospital, New York, New York, USA
    • ,
  • Mary E Duffy, NP

      Affiliations

    • Cardiac Catheterization Laboratory, Cardiovascular Institute, Mount Sinai Hospital, New York, New York, USA
    • ,
  • Michael C Kim, MD

      Affiliations

    • Cardiac Catheterization Laboratory, Cardiovascular Institute, Mount Sinai Hospital, New York, New York, USA
    • ,
  • Samin K Sharma, MD

      Affiliations

    • Cardiac Catheterization Laboratory, Cardiovascular Institute, Mount Sinai Hospital, New York, New York, USA
    • Corresponding Author InformationAddress for reprints: Samin K. Sharma, MD, Mount Sinai Hospital, Box 1030, One Gustave Levy Place, New York, New York 10029-6574, USA.

Received 25 June 2003 ,Revised 5 September 2003 ,Accepted 5 September 2003.

References 

  1. Bertinchant JP, Polge A, Ledermann B, Genet L, Fabbro-Peray P, Raczka F, et al. Relation of minor cardiac troponin I elevation to late cardiac events after uncomplicated elective successful percutaneous transluminal coronary angioplasty for angina pectoris. Am J Cardiol. 1999;84:51–57
  2. Kini A, Marmur J, Kini S, Dangas G, Cocke T, Wallenstein S, et al. Creatine kinase-MB elevation after coronary intervention correlates with diffuse atherosclerosis, and low-to-medium level elevation has a benign clinical course. J Am Coll Cardiol. 1999;34:663–671
  3. Garbarz E, Iung B, Lefevre G, Makita Y, Farah B, Michaud P, et al. Frequency and prognostic value of cardiac troponin I elevation after coronary stenting. Am J Cardiol. 1999;84:515–518
  4. Fuchs S, Kornowski R, Mehran R, Lansky A, Satler L, Pichard A, et al. Prognostic value of cardiac troponin I levels following catheter-based coronary interventions. Am J Cardiol. 2000;85:1077–1082
  5. Wu A, Boden W, McKay R. Long-term follow-up of patients with increased cardiac troponin concentrations following percutaneous coronary intervention. Am J Cardiol. 2002;89:1300–1302
  6. Cantor W, Newby K, Christenson R, Tuttle R, Hasselblad V, Armstrong P, et al. Prognostic significance of elevated troponin I after percutaneous coronary intervention. J Am Coll Cardiol. 2002;39:1738–1744
  7. Fuchs S, Gruberg L, Singh S, Stabile E, Duncan C, Wu H, et al. Prognostic value of cardiac troponin I re-elevation following percutaneous coronary intervention in high-risk patients with acute coronary syndromes. Am J Cardiol. 2001;88:129–133
  8. Saucedo J, Mehran R, Dangas G, Hong M, Lansky A, Kent K, et al. Long-term clinical events following creatine kinase-myocardial band isoenzyme elevation after successful coronary stenting. J Am Coll Cardiol. 2000;35:1134–1141
  9. Ellis S, Chew D, Chan A, Whitlow P, Schneider J, Topol E. Death following creatine kinase-MB elevation after coronary intervention. Identification of an early risk period (importance of creatine kinase-MB level, completeness of revascularization, ventricular function, and probable benefit of statin therapy). Circulation. 2002;106:1205–1210
  10. Kong T, Davidson C, Meyers S, Tauke J, Parker M, Bonow R. Prognostic implication of creatine kinase elevation following elective coronary artery interventions. JAMA. 1997;277:461–466
  11. Stone G, Mehran R, Dangas G, Lansky A, Kornowski R, Leon M. Differential impact on survival of electrocardiographic Q-wave versus enzymatic myocardial infarction after percutaneous intervention (a device-specific analysis of 7147 patients). Circulation. 2001;104:642–647
  12. Bertinchant JP, Larue C, Pernel I, Ledermann B, Fabbro-Peray P, Beck L, et al. Release kinetics of serum cardiac troponin I in ischemic myocardial injury. Clin Biochem. 1996;29:587–594
  13. Shyu K, Kuan P, Cheng J, Hung C. Cardiac troponin T, creatine kinase, and its isoform release after successful percutaneous transluminal coronary angioplasty with or without stenting. Am Heart J. 1998;135:862–867
  14. Antman E, Cohen M, Bernink P, McCabe C, Horacek T, Papuchis G, et al. The TIMI risk score for unstable angina/non-ST elevation MI. A method for prognostication and therapeutic decision making. JAMA. 2000;284:835–842
  15. Morrow D, Cannon C, Rifai N, Frey M, Vicari R, Lakkis N, et al. Ability of minor elevations of troponins I and T to predict benefit from an early invasive strategy in patients with unstable angina and non-ST elevation myocardial infarction. JAMA. 2001;286:2405–2412
  16. Cannon C, Weintraub W, Demopoulos L, Vicari R, Frey M, Lakkis N, et al. Comparison of early invasive and conservatives strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban. N Engl J Med. 2001;334:1879–1887
  17. Hosmer D, Lemeshow S. Applied Survival Analysis: Regression Modeling of Time to Event Data. Wiley Series in Probability and Statistics. New York, NY: Wiley, 1999:180–187

PII: S0002-9149(03)01322-5

doi: 10.1016/j.amjcard.2003.09.006

American Journal of Cardiology
Volume 93, Issue 1 , Pages 18-23 , 1 January 2004

Article Tools

* Image Usage & Resolution