American Journal of Cardiology
Volume 92, Issue 5 , Pages 498-503 , 1 September 2003

Comparison of coronary artery calcium detected by electron beam tomography in patients with to those without symptomatic coronary heart disease

  • Yiling J. Cheng, MD, PhD

      Affiliations

    • The Cooper Institute, Dallas, Texas, USA
    • Corresponding Author InformationAddress for reprints: Yiling J. Cheng, MD, PhD, CDC, 2858 Wood Cook Blvd, Bavieson Bldg, Mail Stop K10, Atlanta, Georgia 38041, USA.
  • ,
  • Timothy S. Church, MD, MPH, PhD

      Affiliations

    • The Cooper Institute, Dallas, Texas, USA
  • ,
  • Thomas E. Kimball, MD

      Affiliations

    • The Cooper Clinic, Dallas, Texas, USA
  • ,
  • Milton Z. Nichaman, MD, SCD

      Affiliations

    • The Cooper Institute, Dallas, Texas, USA
  • ,
  • Benjamin D. Levine, MD

      Affiliations

    • Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, Texas, USA
    • The University of Texas Southwestern Medical Center, Dallas, Texas, USAand the Centers for Disease Control, Atlanta, Georgia.
  • ,
  • Darren K. McGuire, MD, MHSc

      Affiliations

    • The University of Texas Southwestern Medical Center, Dallas, Texas, USAand the Centers for Disease Control, Atlanta, Georgia.
  • ,
  • Steven N. Blair, PED

      Affiliations

    • The Cooper Institute, Dallas, Texas, USA

Received 22 January 2003 ,Revised 19 May 2003 ,Accepted 19 May 2003.

References 

  1. Blankenhorn DH. Coronary arterial calcification (a review). Am J Med Sci. 1961;242:41–49
  2. Detrano R, Froelicher V. A logical approach to screening for coronary artery disease. Ann Intern Med. 1987;106:846–852
  3. Newman AB, Naydeck BL, Sutton-Tyrrell K, Feldman A, Edmundowicz D, Kuller LH. Coronary artery calcification in older adults to age 99 (prevalence and risk factors). Circulation. 2001;104:2679–2684
  4. Janowitz WR, Agatston AS, Kaplan G, Viamonte MJ. Differences in prevalence and extent of coronary artery calcium detected by ultrafast computed tomography in asymptomatic men and women. Am J Cardiol. 1993;72:247–254
  5. Wong ND, Kouwabunpat D, Vo AN, Detrano RC, Eisenberg H, Goel M, et al. Coronary calcium and atherosclerosis by ultrafast computed tomography in asymptomatic men and women (relation to age and risk factors). Am Heart J. 1994;127:422–430
  6. Blair SN, Kohl HW, Paffenbarger RSJ, Clark DG, Cooper KH, Gibbons LW. Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA. 1989;262:2395–2401
  7. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte MJ, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827–832
  8. Wang S, Detrano RC, Secci A, Tang W, Doherty TM, Puentes G, et al. Detection of coronary calcification with electron-beam computed tomography (evaluation of interexamination reproducibility and comparison of three image-acquisition protocols). Am Heart J. 1996;132:550–558
  9. Blair SN, Kampert JB, Kohl HW, Barlow CE, Macera CA, Paffenbarger RSJ, et al. Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA. 1996;276:205–210
  10. Balke B, Ware RW. An experimental study of physical fitness in Air Force personnel. US Armed Forces Med J. 1959;10:675–688
  11. Pollock ML, Foster C, Schmidt D, Hellman C, Linnerud AC, Ward A. Comparative analysis of physiologic responses to three different maximal graded exercise test protocols in healthy women. Am Heart J. 1982;103:363–373
  12. Pollock ML, Bohannon RL, Cooper KH, Ayres JJ, Ward A, White SR, et al. A comparative analysis of four protocols for maximal treadmill stress testing. Am Heart J. 1976;92:39–46
  13. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2000;23:S4–S19
  14. Greenland S. Modeling and variable selection in epidemiologic analysis. Am J Public Health. 1989;79:340–349
  15. Rumberger JA, Sheedy PF, Breen JF, Schwartz RS. Electron beam computed tomographic coronary calcium score cutpoints and severity of associated angiographic lumen stenosis. J Am Coll Cardiol. 1997;29:1542–1548
  16. Sangiorgi G, Rumberger JA, Severson A, Edwards WD, Gregoire J, Fitzpatrick LA, et al. Arterial calcification and not lumen stenosis is highly correlated with atherosclerotic plaque burden in humans (a histologic study of 723 coronary artery segments using nondecalcifying methodology). J Am Coll Cardiol. 1998;31:126–133
  17. Wexler L, Brundage B, Crouse J, Detrano R, Fuster V, Maddahi J, et al. Coronary artery calcification (pathophysiology, epidemiology, imaging methods, and clinical implications. A statement for health professionals from the American Heart Association Writing Group). Circulation. 1996;94:1175–1192
  18. Detrano R, Hsiai T, Wang S, Puentes G, Fallavollita J, Shields P, et al. Prognostic value of coronary calcification and angiographic stenoses in patients undergoing coronary angiography. J Am Coll Cardiol. 1996;27:285–290
  19. Hoff JA, Chomka EV, Krainik AJ, Daviglus M, Rich S, Kondos GT. Age and gender distributions of coronary artery calcium detected by electron beam tomography in 35,246 adults. Am J Cardiol. 2001;87:1335–1339
  20. Mitchell TL, Pippin JJ, Devers SM, Kimball TE, Cannaday JJ, Gibbons LW, et al. Age- and sex-based nomograms from coronary artery calcium scores as determined by electron beam computed tomography. Am J Cardiol. 2001;87:453–456
  21. Wei M, Kampert JB, Barlow CE, Nichaman MZ, Gibbons LW, Paffenbarger RSJ, et al. Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA. 1999;282:1547–1553
  22. Detrano RC, Wong ND, Doherty TM, Shavelle RM, Tang W, Ginzton LE, et al. Coronary calcium does not accurately predict near-term future coronary events in high-risk adults. Circulation. 1999;99:2633–2638
  23. Secci A, Wong N, Tang W, Wang S, Doherty T, Detrano R. Electron beam computed tomographic coronary calcium as a predictor of coronary events (comparison of two protocols). Circulation. 1997;96:1122–1129
  24. Blair SN, Goodyear NN, Gibbons LW, Cooper KH. Physical fitness and incidence of hypertension in healthy normotensive men and women. JAMA. 1984;252:487–490

 This research was supported in part by U.S. Public Health Service research grants R01HL62508 and R01AG06945 from the National Institutes of Health, Bethesda, Maryland, and by contributions from several individuals.

PII: S0002-9149(03)00714-8

doi: 10.1016/S0002-9149(03)00714-8

American Journal of Cardiology
Volume 92, Issue 5 , Pages 498-503 , 1 September 2003