American Journal of Cardiology
Volume 92, Issue 3 , Pages 334-336 , 1 August 2003

Relation of aggressiveness of lipid-lowering treatment to changes in calcified plaque burden by electron beam tomography

  • Harvey S. Hecht, MD

      Affiliations

    • Beth Israel Medical Center, New York, New York, USA
    • Corresponding Author InformationDr. Hecht’s address is: Beth Israel Medical Center, Phillips Ambulatory Care Center, 10 Union Square East, New York, New York 10003, USA.
  • ,
  • S.Mitchell Harman, MD, PhD

      Affiliations

    • Kronos Longevity Research Institute, Phoenix, Arizona, USA

Received 1 November 2002 ,Revised 16 April 2003 ,Accepted 16 April 2003.

References 

  1. Hecht HS, Superko HR, Smith LK, McGolgan BP. Relation of coronary artery calcium identified by electron beam tomography to serum lipoprotein levels and implications for treatment. Am J Cardiol. 2001;87:406–412
  2. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827–833
  3. Callister TQ, Cooil B, Raya SP, Lippolis NJ, Russo DJ, Raggi P. Coronary artery disease (improved reproducibility of calcium scoring with an electron-beam CT volumetric method). Radiology. 1998;208:807–814
  4. Lipid Research Clinics Manual of Laboratory Operations. Lipid and lipoprotein analysis. HEW Publication No. NIH 75–628. Washington, DC: US Government Printing Office, 1974
  5. Forrester JS, Bairey-Merz N, Kaul S. The aggressive low density lipoprotein controversy. J Am Coll Cardiol. 2000;36:1419–1425
  6. Callister T, Raggi P, Cooil B, Lippolis NJ, Russo DJ. Effect of HMG-CoA reductase inhibitors on coronary artery disease as assessed by electron-beam computed tomography. N Engl J Med. 1998;339:1972–1978
  7. Budoff MJ, Lane KL, Bakhsheshi H, Mao S, Grassmann BO, Friedman BC, et al. Rates of progression of coronary calcium by electron beam tomography. Am J Cardiol. 2000;86:8–11
  8. Achenbach S, Ropers D, Pohle K, Leber A, Thilo C, Knez A, et al  A prospective evaluation. Circulation. 20002;106:1077–1082
  9. Hecht HS, Harman SM. Atorvastatin versus simvastatin in primary prevention (effect on progression of subclinical atherosclerosis determined by electron beam tomography). Am J Cardiol. 2003;91:42–45
  10. Hecht HS, Harman SM. Comparison of statin monotherapy versus statin and niacin combination therapy in primary prevention (effect on change in calcified plaque burden). Am J Cardiol. 2003;91:348–351
  11. Hecht HS, Harman SM. Evaluation by electron beam tomography of changes in calcified coronary plaque in treated and untreated patients and relation to serum lipid levels. Am J Cardiol 2003;91:1131–1134
  12. Raggi P, Callister TQ, Cooil B, He Z, Lippolis NJ, Russo DJ, et al. Identification of patients at increased risk of first unheralded acute myocardial infarction by electron beam computed tomography. Circulation. 2000;101:850–855
  13. Wong ND, Hsu JC, Detrano RC, Diamond G, Eisenberg H, Gardin JM. Coronary artery calcium evaluation by electron beam computed tomography and its relation to new cardiovascular events. Am J Cardiol. 2000;86:495–498
  14. Arad Y, Spadaro LA, Goodman K, Newstein D, Guerci AD. Prediction of coronary events with electron beam computed tomography. J Am Coll Cardiol. 2000;36:1253–1260
  15. Budoff MJ, Raggi P. Coronary artery disease progression assessed by electron beam computed tomography. Am J Cardiol. 2001;88(suppl):51E–55E
  16. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals (a randomised placebo-controlled trial). Lancet. 2002;360:7–22
  17. LaRosa JC. Pleiotropic effects of statins and their clinical significance. Am J Cardiol. 2001;88:291–293

PII: S0002-9149(03)00642-8

doi: 10.1016/S0002-9149(03)00642-8

American Journal of Cardiology
Volume 92, Issue 3 , Pages 334-336 , 1 August 2003