American Journal of Cardiology
Volume 90, Issue 10 , Pages 1118-1122 , 15 November 2002

Effects of pentoxifylline on cytokine profiles and left ventricular performance in patients with decompensated congestive heart failure secondary to idiopathic dilated cardiomyopathy

  • Karen Sliwa, MD

      Affiliations

    • Heart Failure Research Unit, Department of Cardiology, Chris-Hani Baragwanath Hospital, Johannesburg, South Africa
    • Corresponding Author InformationAddress for reprints: Karen Sliwa, MD, Department of Cardiology, Chris Hani Baragwanath Hospital, P.O. Bertsham, 2013, Johannesburg, South Africa.
    • ,
  • Angela Woodiwiss, PhD

      Affiliations

    • the School of Physiology, University of the Witwatersrand, Johannesburg, South Africa
    • ,
  • Geoffrey Candy, PhD

      Affiliations

    • Heart Failure Research Unit, Department of Cardiology, Chris-Hani Baragwanath Hospital, Johannesburg, South Africa
    • ,
  • Danelle Badenhorst, MSc

      Affiliations

    • the School of Physiology, University of the Witwatersrand, Johannesburg, South Africa
    • ,
  • Carlos Libhaber, MD

      Affiliations

    • Heart Failure Research Unit, Department of Cardiology, Chris-Hani Baragwanath Hospital, Johannesburg, South Africa
    • ,
  • Gavin Norton, MD, PhD

      Affiliations

    • the School of Physiology, University of the Witwatersrand, Johannesburg, South Africa
    • ,
  • Daniel Skudicky, MD

      Affiliations

    • Heart Failure Research Unit, Department of Cardiology, Chris-Hani Baragwanath Hospital, Johannesburg, South Africa
    • ,
  • Pinhas Sareli, MD

      Affiliations

    • Heart Failure Research Unit, Department of Cardiology, Chris-Hani Baragwanath Hospital, Johannesburg, South Africa

Received 29 April 2002 ,Revised 15 July 2002 ,Accepted 15 July 2002.

References 

  1. Torre-Amione G, Kapadia S, Benedict C, Oral H, Young JB, Mann DL. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction (a report from the Studies of Left Ventricular Dysfunction (SOLVD)). J Am Coll Cardiol. 1996;27:1201–1206
  2. Seta Y, Shan K, Bozkurt ETAL. Basic mechanism in heart failure (the cytokine hypothesis). J Cardiac Failure. 1996;2:243–249
  3. Baumgarten G, Knuefermann P, Mann D. Cytokines as emerging targets in the treatment of heart failure. Trends Cardio Med. 2000;10:216–223
  4. Hegewisch S, Weh HJ, Hossfeld DK. TNF-induced cardiomyopathy. Lancet. 1990;335:294–295
  5. Sliwa K, Skudicky D, Candy G, Wisenbaugh T, Sareli P. Randomised investigation of effects of pentoxifylline on left ventricular performance in idiopathic dilated cardiomyopathy. Lancet. 1998;351:1091–1093
  6. Skudicky D, Bergmann A, Sliwa K, Candy G, Sareli P. Beneficial effects of pentoxifylline in patients with idiopathic dilated cardiomyopathy treated with an angiotensin-converting enzyme inhibitor and carvedilol. Circulation. 2001;103:1083–1090
  7. Suda T, Takahashi T, Golstein P, Nagata S. Molecular cloning and expression of the Fas ligand, a novel member of the tumour necrosis factor family. Cell. 1993;75:1169–1178
  8. Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME. Apoptosis signaling by death receptors. Eur J Biochem. 1998;254:439–459
  9. Reiber JHC. Quantitative analysis of left ventricular function from equilibrium gated blood scintigrams (an overview of computer methods). Eur J Nucl Med. 1985;10:97–110
  10. Sahn DJ, DeMaria A, Kisslo J, Weyman A. The committee on M-mode standardization of the American Society of Echocardiography (results of a survey of echocardiographic measurements). Circulation. 1978;58:1072–1083
  11. Giannuzzi P, Temporelli PL, Bosimini E, Silva P, Imperado A, Cassa U, et al. Independent and incremental prognostic value of Doppler-derived mitral deceleration time of early filling in both symptomatic and asymptomatic patients with left ventricular dysfunction. J Am Coll Cardiol. 1996;28:383–390
  12. Levine B, Kalman J, Mayer L, Fillit HM, Packer M. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med. 1990;323:236–241
  13. Aukrust P, Ueland T, Lien E, Bendtzen K, Muller F, Andreassen AK, et al. Cytokine network in congestive heart failure secondary to ischaemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 1999;83:376–382
  14. Nishigaki K, Minatogushi S, Seishima M, Asano K, Noda T, Yasuda N, Sano H, Kumada H, Takemura M, Noma A, et al. Plasma Fas Ligand, an inducer of apoptosis, and plasma soluble Fas, an inhibitor of apoptosis, in patients with chronic congestive heart failure. J Am Coll Cardiol 1997;29:1214–1220
  15. D’Hellencourt CL, Diaw L, Cornillet P, Guenounou M. Differential regulation of TNF-alpha, IL-beta, IL-6, IL-8, TNF beta, and IL-10 by pentoxifylline. Int Immunopharmacol. 1996;18:739–748
  16. Packer M, Coats A, Fowler M, Katus H, Krum H, Mohacsi P, et al  Effect of carvedilol on survival in severe chronic heart failure. COPERNICUS. N Engl J Med. 2001;344:1651–1658

☆ This study was supported by the H.E. Griffin Charitable Trust and the University of the Witwatesrand Research Council, Johannesburg, South Africa.

PII: S0002-9149(02)02779-0

American Journal of Cardiology
Volume 90, Issue 10 , Pages 1118-1122 , 15 November 2002

Article Tools

* Image Usage & Resolution