American Journal of Cardiology
Volume 88, Issue 9 , Pages 1060-1063 , 1 November 2001

Effect of chronic infusion of epoprostenol on echocardiographic right ventricular myocardial performance index and its relation to clinical outcome in patients with primary pulmonary hypertension

  • Igal Sebbag, MD

      Affiliations

    • Echocardiography Laboratory, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    • ,
  • Lawrence G. Rudski, MD

      Affiliations

    • Echocardiography Laboratory, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    • ,
  • Judith Therrien, MD

      Affiliations

    • Echocardiography Laboratory, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    • ,
  • Andrew Hirsch, MD

      Affiliations

    • the Center for Pulmonary Vascular Disease, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    • ,
  • David Langleben, MD

      Affiliations

    • Corresponding Author InformationDr. Langleben’s address is: Room E-258, Jewish General Hospital, 3755 Cote Ste-Catherine, Montreal, Quebec H3T 1E2 Canada.
    • the Center for Pulmonary Vascular Disease, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada

Received 10 April 2001 ,Revised 15 June 2001 ,Accepted 15 June 2001.

References 

  1. Eidem BW, Tei C, O’Leary PW, Cetta F, Seward JB. Nongeometric quantitative assessment of right and left ventricular function: myocardial performance index in normal children and patients with Ebstein anomaly. J Am Soc Echocardiogr. 1998;11:849–856
  2. Tei C, Ling LH, Hodge DO, Bailey KR, Oh JH, Rodeheffer RJ, et al. New index of combined systolic and diastolic myocardial performance (a simple and reproducible measure of cardiac function—a study in normals and dilated cardiomyopathy). J Cardiol. 1998;26:357–366
  3. Tei C. New non-invasive index for combined systolic and diastolic ventricular function. J Cardiol. 1998;26:135–136
  4. Tei C, Dujardin KS, Hodge DO, Bailey KR, McGoon MD, Tajik AJ, et al. Doppler echocardiographic index for assessment of global ventricular function. J Am Soc Echocardiogr. 1998;9:838–847
  5. Rich S, Dantzker DR, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, et al  Primary pulmonary hypertension (a national prospective study). Ann Intern Med. 1998;107:216–223
  6. Fuster V, Steele PM, Edwards WD, Gersh BJ, McGoon MD, Frye RL. Primary pulmonary hypertension: natural history and the importance of thrombosis. Circulation. 1998;70:580–587
  7. D’Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, et al  Survival in patients with primary pulmonary hypertension (results from a national public registry). Ann Intern Med. 1998;115:343–349
  8. Vane JR, Botting RM. Pharmacodynamic profile of prostacyclin. Am J Cardiol. 1998;75:3A–10A
  9. Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, et al  A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N Engl J Med. 1998;334:296–301
  10. Badesch DB, Tapson VF, McGoon MD, Brundage BH, Rubin LJ, Wigley FM, et al  Continuous intravenous epoprostenol for pulmonary hypertesion due to scleroderma spectrum of disease. A randomized, conrolled trial. Ann Intern Med. 1998;132:425–434
  11. McLaughlin VV, Genthner DE, Panella MM, Rich S. Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension. N Engl J Med. 1998;338:273–277
  12. Hinderliter AL, Willis PW, Barst RJ, Rich S, Rubin LJ, Badesch DB, et al  Effects of long-term infusion of prostacyclin (epoprostenol) on echocardiographic measures of right ventricular structure and function in primary pulmonary hypertention. Circulation. 1997;1479–1486

☆ This study was supported in part by the Bank of Montreal Center for the Study of Heart Disease in Women, Montreal, Quebec, Canada.

PII: S0002-9149(01)01995-6

American Journal of Cardiology
Volume 88, Issue 9 , Pages 1060-1063 , 1 November 2001

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