American Journal of Cardiology
Volume 79, Issue 3 , Pages 328-333 , 1 February 1997

Enalapril Reduces QTc Dispersion in Mild Congestive Heart Failure Secondary to Coronary Artery Disease

  • Craig S. Barr, MB, MRCP

      Affiliations

    • Departments of Clinical Pharmacology and Medical Physics, Ninewells Hospital and Medical School, Dundee, United Kingdom
  • ,
  • Abdelwahab A. Naas, MB

      Affiliations

    • Departments of Clinical Pharmacology and Medical Physics, Ninewells Hospital and Medical School, Dundee, United Kingdom
  • ,
  • Michael Fenwick

      Affiliations

    • Departments of Clinical Pharmacology and Medical Physics, Ninewells Hospital and Medical School, Dundee, United Kingdom
  • ,
  • Allan D. Struthers, MD

      Affiliations

    • Departments of Clinical Pharmacology and Medical Physics, Ninewells Hospital and Medical School, Dundee, United Kingdom
    • Corresponding Author InformationAllan D. Struthers, MD, Department of Clinical Pharmacology, Ninewells Hospital & Medical School, Dundee DD1 9SY, United Kingdom.

Received 30 May 1996 ,Accepted 7 August 1996.

References 

  1. Ho KKL, Pinsky JL, Kannel WB, Levy D. The epidemiology of heart failure: the Framingham Study. J Am Coll Cardiol 1993;22:6A–3A.
  2. McDonagh TA, Morrison CE, McMurray JJ, Duncan D, Ford I, Tunstall-Pedoe H, et al. The prevalence of left ventricular dysfunction in North Glasgow (abstr). Circulation. 1994;90(suppl I):I-282
  3. Cohn JN, Levine TB, Olivari MT, Garberg V, Lura D, Francis CG, et al. Plasma norepinephrine as a guide to prognosis in chronic congestive heart failure. N Engl J Med. 1984;311:819–823
  4. Francis GS, Bousalis PJ. Mechanism of death in patients with congestive cardiac failure: the change in plasma norepinephrine and its relation to sudden death. Cardioscience. 1990;1:29–32
  5. Barr CS, Naas A, Freeman M, Lang CC, Struthers AD. QT dispersion and sudden unexpected death in chronic heart failure. Lancet. 1994;343:327–329
  6. The CONSENSUS Trial Study Group . Effect of enalapril on mortality in severe congestive heart failure. N Engl J Med. 1987;326:1429–1435
  7. SOLVD Investigators . Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med. 1991;325:293–302
  8. Cohn JN, Johnson G, Ziesche MS, Cobb F, Francis G, Tristan F, et al. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med. 1991;325:303–310
  9. Gottlieb SS, Weir MR. Renal effects of angiotensin-converting enzyme inhibition in congestive heart failure. Am J Cardiol. 1990;66(suppl):14D–21D
  10. Ichikawa I, Pfeffer JM, Pfeffer MA, Hestetter TH, Brenner BM. Role of angiotensin II in the altered renal function of congestive heart failure. Circ Res. 1984;55:669–675
  11. Chobanian AV, Burrows BA, Hollander W. Body and fluid electrolyte composition in cardiac patients with severe heart failure disease but without peripheral edema. Circulation. 1961;24:743–753
  12. Tasxe WN, Mahler FT, Taylor WF. Effective renal plasma flow: estimation from theoretical volumes of distrubution of intravenously injected 131I-orthoiodohippurate. Mayo Clin Proc. 1971;45:524–531
  13. Perrone RD, Steinman TI, Beck GJ, Skibinski CI, Royal HD, Lawlor M, et al. Utility of radioisotope filtration markers in chronic renal insufficiency: simultaneous comparison of 125I-iothalamate, 169yb-DTPA, 99 mTc-DTPA and inulin. Am J Kidney Dis. 1990;16:224–235
  14. Morton JJ, Webb DJ. Measurement of plasma angiotensin II. Clin Sci. 1985;68:483–484
  15. Motwani JG, Fenwick MK, McAlpine HM, Kennedy N, Struthers AD. Effectiveness of captopril in reversing renal vasoconstriction after Q wave acute myocardial infarction. Am J Cardiol. 1993;71:281–286
  16. Motwani JG, Fenwick MK, Morton JJ, Struthers AD. Furosemide induced natriuresis is augmented by ultra low dose captopril but not by standard doses in chronic heart failure. Circulation. 1992;86:439–445
  17. Higham PD, Campbell RWF. QT dispersion. Br Heart J. 1994;71:508–509
  18. Buja G, Miorelli M, Turrini P, Melacini P, Nava A. Comparison of QT dispersion in hypertrophic cardiomyopathy between patients with and without ventricular arrhythmias and sudden death. Am J Cardiol. 1993;72:973–976
  19. Darbar D, Luck J, Davidson N, Pringle T, Main G, McNeill G, et al. Sensitivity and specificity of QTc dispersion for identification of risk of cardiac death in patients with peripheral vascular disease. Br Med J. 1996;312:874–879
  20. Zabel M, Portnoy S, Franz M. ECG indexes of dispersion of ventricular repolarization: an isolated heart validation study. J Am Coll Cardiol. 1995;25:746–752
  21. Merx W, Yoon MS, Han J. The role of local disparity on conduction and recovery time on ventricular vulnerability to fibrillation. Am Heart J. 1977;94:603–610
  22. Bogun F, Chan KK, Harvey M, Goyal R, Castellani M, Niebauer M, et al. QT dispersion in nonsustained ventricular tachycardia and coronary artery disease. Am J Cardiol. 1996;77:256–259
  23. Yusuf S, Pepine CJ, Garces C, Pouleur H, Salem D, Kostis J, et al. Effect of enalapril on myocardial infarction and unstable angina in patients with low ejection fractions. Lancet. 1992;340:1173–1178
  24. Lee MS, Cross SJ, Rawles J, Walton S, Jennings KP. QTc dispersion in patients with coronary artery disease: effect of exercise, dobutamine and dipyridamole myocardial stress (abstr). Eur Heart J. 1993;14:210
  25. TEAM-2 Moreno FL, Villaneuva T, Karagounis LA, Anderson JL. Reduction in QT interval dispersion by successful thrombolytic therapy in acute myocardial infarction. Circulation. 1994;90:94–100
  26. Volpe M, Tritto C, Testa U, Rao MAE, Martucci R, Mirante A, et al. Blood levels of erythropoietin in congestive heart failure and correlation with clinical, hemodynamic and hormonal profiles. Am J Cardiol. 1994;74:468–473
  27. Ernst E. hematocrit and cardiovascular risk. J Intern Med 1995;527–528.

PII: S0002-9149(96)00756-4

American Journal of Cardiology
Volume 79, Issue 3 , Pages 328-333 , 1 February 1997