American Journal of Cardiology
Volume 104, Issue 6 , Pages 750-757 , 15 September 2009

Acute Effects of Statin Therapy on Coronary Atherosclerosis Following an Acute Coronary Syndrome

  • Josep Rodés-Cabau, MD

      Affiliations

    • Quebec Heart and Lung Institute, Quebec, Quebec, Canada
    • Corresponding Author InformationCorresponding author: Tel.: 418-656-8711; fax: 418-656-4544
    • Drs. Josep Rodés-Cabau and Jean-Claude Tardif contributed equally to this article.
    • ,
  • Jean-Claude Tardif, MD

      Affiliations

    • Montreal Heart Institute, Montreal, Quebec, Canada
    • Corresponding Author InformationCorresponding author: Tel.: 514-376-3330
    • Drs. Josep Rodés-Cabau and Jean-Claude Tardif contributed equally to this article.
    • ,
  • Mariève Cossette, MSc

      Affiliations

    • Montreal Heart Institute Coordinating Center, Montreal, Quebec, Canada
    • ,
  • Olivier F. Bertrand, MD, PhD

      Affiliations

    • Quebec Heart and Lung Institute, Quebec, Quebec, Canada
    • ,
  • Reda Ibrahim, MD

      Affiliations

    • Montreal Heart Institute, Montreal, Quebec, Canada
    • ,
  • Eric Larose, MD

      Affiliations

    • Quebec Heart and Lung Institute, Quebec, Quebec, Canada
    • ,
  • Jean Grégoire, MD

      Affiliations

    • Montreal Heart Institute, Montreal, Quebec, Canada
    • ,
  • Philippe L. L'Allier, MD

      Affiliations

    • Montreal Heart Institute, Montreal, Quebec, Canada
    • ,
  • Marie-Claude Guertin, PhD

      Affiliations

    • Montreal Heart Institute Coordinating Center, Montreal, Quebec, Canada

Received 12 February 2009 ,Revised 5 May 2009 ,Accepted 5 May 2009.

References 

  1. Cannon CP, Braunwauld E, McCabe CH, Rader DJ, Rouleau JL, Belder R, et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med. 2004;350:1495–1504
  2. Schwartz GG, Olsson AG, Ezekowitz MD, Ganz P, Oliver MF, Waters D, et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study; a randomized controlled trial. JAMA. 2001;285:1711–1718
  3. Stenestrand U, Wallentin L. Early statin treatment following acute myocardial infarction and 1-year survival. JAMA. 2001;285:430–436
  4. Aronow HD, Topol EJ, Roe MT, Houghtaling PL, Wolski KE, Lincoff AM, et al. Effect of lipid-lowering therapy on early mortality after acute coronary syndromes: an observational study. Lancet. 2001;357:1063–1068
  5. Guédès A, Tardif JC. Intravascular ultrasound assessment of atherosclerosis. Curr Atheroscler Rep. 2004;6:219–224
  6. Nicholls SJ, Sipahi I, Schoenhagen P, Crowe T, Tuzcu EM, Nissen SE. Application of intravascular ultrasound in anti-atherosclerotic drug development. Nat Rev Drug Discov. 2006;5:485–492
  7. Jensen LO, Thayssen P, Pedersen KE, Stender S, Haghfelt T. Regression of coronary atherosclerosis by simvastatin (A serial intravascular ultrasound study). Circulation. 2004;110:265–270
  8. Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, et al. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis (The ASTEROID trial). JAMA. 2006;295:1556–1565
  9. Nissen SE, Tuzcu EM, Schoenhagen P, Brown BG, Ganz P, Vogel RA, et al. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis (A randomized controlled trial). JAMA. 2004;291:1071–1080
  10. Tardif JC, Grégoire J, L'Allier P, Ibrahim R, Lespérance J, Heinonen TM, et al. Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis (A randomized controlled trial). JAMA. 2007;297:1675–1682
  11. Okazaki S, Yokoyama T, Miyauchi K, Shimada K, Kurata T, Sato H, et al. Early statin treatment in patients with acute coronary syndrome (Demonstration of the beneficial effect on atherosclerotic lesions by serial volumetric intravascular ultrasound analysis during half a year after coronary event: the ESTABLISH study). Circulation. 2004;110:1061–1068
  12. Ray KK, Cannon CP, McCabe CH, Cairns R, Tonkin AM, Sacks FM, et al. Early and late benefits of high-dose atorvastatin in patients with acute coronary syndromes: results from the PROVE IT-TIMI 22 trial. J Am Coll Cardiol. 2005;46:1405–1410
  13. Ray KK, Cannon CP. Early time to benefit with intensive statin treatment: could it be the pleiotropic effects?. Am J Cardiol. 2005;96(suppl 5A):54F–60F
  14. Wiviott SD, de Lemos JA, Cannon CP, Blazing M, Murphy SA, McCabe CH, et al. A tale of two trials: a comparison of the post-acute coronary syndrome lipid-lowering trials A to Z and PROVE IT-TIMI 22. Circulation. 2006;113:1406–1414
  15. Nissen SE, Tuzcu EM, Schoenhagen P, Crowe T, Sasiela WJ, Tsai J, et al. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N Engl J Med. 2005;352:29–38
  16. Nicholls SJ, Tuzcu EM, Sipahi I, Grasso AW, Schoenhagen P, Hu T, et al. Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis. JAMA. 2007;297:499–508
  17. Lemieux I, Lamarche B, Couillard C, Pascot A, Cantin B, Bergeron J, et al. Total cholesterol/HDL cholesterol ratio vs. LDL cholesterol/HDL cholesterol ratio as indices of ischemic heart disease risk in men: the Quebec Cardiovascular Study. Arch Intern Med. 2001;161:2685–2692
  18. Jeppesen J, Hein HO, Suadicani P, Gyntelberg F. Relation of high TG-low HDL cholesterol and LDL cholesterol to the incidence of ischemic heart disease (An 8-year follow-up in the Copenhagen Male Study). Arterioscler Thromb Vasc Biol. 1997;17:1114–1120
  19. Bogaty P, Boyer L, Simard S, Dauwe F, Dupuis R, Verret B, et al. Clinical utility of C-reactive protein measured at admission, hospital discharge, and 1 month later to predict outcome in patients with acute coronary disease (The RISCA (Recurrence and Inflammation in the Acute Coronary Syndromes) study). J Am Coll Cardiol. 2008;51:2339–2346

 This study was supported by the Cardiovascular Health Network of the Fonds de la Recherche en Santé du Québec, Montreal, Quebec, Canada. The ERASE trial was funded by CSL Ltd, Parkeville, Victoria, Australia.

PII: S0002-9149(09)01044-3

doi: 10.1016/j.amjcard.2009.05.009

American Journal of Cardiology
Volume 104, Issue 6 , Pages 750-757 , 15 September 2009

Article Tools

* Image Usage & Resolution