American Journal of Cardiology
Volume 104, Issue 4 , Pages 554-558 , 15 August 2009

Does Peak Oxygen Pulse Complement Peak Oxygen Uptake in Risk Stratifying Patients With Heart Failure?

  • Ricardo B. Oliveira, PhD

      Affiliations

    • Gama Filho University, Rio de Janeiro, Brazil
    • VA Palo Alto Health Care System, Cardiology Division, Stanford University, Palo Alto, California
    • Corresponding Author InformationCorresponding author: Tel: 650-493-5000 ext. 6-4661; fax: 650-852-3473
    • ,
  • Jonathan Myers, PhD

      Affiliations

    • VA Palo Alto Health Care System, Cardiology Division, Stanford University, Palo Alto, California
    • ,
  • Claudio Gil S. Araújo, MD, PhD

      Affiliations

    • Gama Filho University, Rio de Janeiro, Brazil
    • Clinica de Medicina do Exercicio, Rio de Janeiro, Brazil
    • ,
  • Ross Arena, PhD

      Affiliations

    • Virginia Commonwealth University Medical Center, Richmond, Virginia
    • ,
  • Sandra Mandic, PhD

      Affiliations

    • VA Palo Alto Health Care System, Cardiology Division, Stanford University, Palo Alto, California
    • ,
  • Daniel Bensimhon, MD

      Affiliations

    • LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina
    • ,
  • Joshua Abella, MD

      Affiliations

    • VA Palo Alto Health Care System, Cardiology Division, Stanford University, Palo Alto, California
    • ,
  • Paul Chase, MEd

      Affiliations

    • LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina
    • ,
  • Marco Guazzi, MD, PhD

      Affiliations

    • University of Milano, Sao Paolo Hospital, Milan, Italy
    • ,
  • Peter Brubaker, PhD

      Affiliations

    • Wake Forest University School of Medicine, Winston-Salem, North Carolina
    • ,
  • Brian Moore, MS

      Affiliations

    • Wake Forest University School of Medicine, Winston-Salem, North Carolina
    • ,
  • Dalane Kitzman, MD

      Affiliations

    • Wake Forest University School of Medicine, Winston-Salem, North Carolina
    • ,
  • Mary Ann Peberdy, MD

      Affiliations

    • Virginia Commonwealth University Medical Center, Richmond, Virginia

Received 10 February 2009 ,Revised 6 April 2009 ,Accepted 6 April 2009.

References 

  1. Munhoz EC, Hollanda R, Vargas JP, Silveira CW, Lemos AL, Hollanda RM, et al. Flattening of oxygen pulse during exercise may detect extensive myocardial ischemia. Med Sci Sports Exerc. 2007;39:1221–1226
  2. Whipp BJ, Higgenbotham MB, Cobb FC. Estimating exercise stroke volume from asymptotic oxygen pulse in humans. J Appl Physiol. 1996;81:2674–2679
  3. Chaudhry S, Arena R, Wasserman K, Hansen JE, Lewis GD, Myers J, et al. Exercise-induced myocardial ischemia detected by cardiopulmonary exercise testing. Am J Cardiol. 2009;103:615–619
  4. Oliveira RB, Myers J, Araújo CGS, Abella J, Mandic S, Froelicher V. Maximal exercise oxygen pulse as a predictor of mortality among male veterans referred for exercise testing. Eur J Cardiovasc Prev Rehabil. 2009;April 7 [epub ahead of print]
  5. Cohen-Solal A, Barnier P, Pessione F, Seknadji P, Logeart D, Laperche T, et al. Comparison of the long-term prognostic value of peak exercise oxygen pulse and peak oxygen uptake in patients with chronic heart failure. Heart. 1997;78:572–576
  6. Lavie CJ, Milani RV, Mehra MR. Peak exercise oxygen pulse and prognosis in chronic heart failure. Am J Cardiol. 2004;93:588–593
  7. Chase P, Arena R, Myers J, Abella J, Peberdy MA, Guazzi M, et al. Relation of the prognostic value of ventilatory efficiency to body mass index in patients with heart failure. Am J Cardiol. 2008;101:348–352
  8. Myers J, Arena R, Dewey F, Bensimhon D, Abella J, Hsu L, et al. A cardiopulmonary exercise testing score for predicting outcomes in patients with heart failure. Am Heart J. 2008;156:1177–1183
  9. Wasserman K, Hansen JE, Sue DY, Casaburi R, Whipp BJ. Principles of Exercise Testing and Interpretation. Baltimore, Maryland: Lippincott, Williams & Wilkins; 2004;
  10. Arena R, Myers J, Abella J, Pinkstaff S, Brubaker P, Moore B, et al. Determining the preferred percent-predicted equation for peak oxygen consumption in patients with heart failure. Circ Heart Fail. 2009;2:113–120
  11. Wagenmakers EJ, Farrell S. AIC model selection using Akaike weights. Psychon Bull Rev. 2004;11:192–196
  12. Mancini DM, Eisen H, Kussmaul W, Mull R, Edmunds LH, Wilson JR. Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation. 1991;83:778–786
  13. Arena R, Myers J, Abella J, Peberdy MA, Bensimhon D, Chase P, et al. Development of a ventilatory classification system in patients with heart failure. Circulation. 2007;115:2410–2417
  14. Arena R, Myers J, Abella J, Peberdy MA, Pinkstaff S, Bensimhon D, et al. Prognostic value of timing and duration characteristics of exercise oscillatory ventilation in patients with heart failure. J Heart Lung Transplant. 2008;27:341–347
  15. Arena R, Myers J, Hsu L, Peberdy MA, Pinkstaff S, Bensimhon D, et al. The minute ventilation/carbon dioxide production slope is prognostically superior to the oxygen uptake efficiency slope. J Card Fail. 2007;13:462–469
  16. Corra U, Mezzani A, Bosimini E, Scapellato F, Imparato A, Giannuzzi P. Ventilatory response to exercise improves risk stratification in patients with chronic heart failure and intermediate functional capacity. Am Heart J. 2002;143:418–426
  17. Arena R, Myers J, Aslam SS, Varughese EB, Peberdy MA. Peak VO2 and VE/VCO2 slope in patients with heart failure: a prognostic comparison. Am Heart J. 2004;147:354–360
  18. Pollock ML, Jackson AS. Research progress in validation of clinical methods of assessing body composition. Med Sci Sports Exerc. 1984;16:606–615
  19. Arena R, Guazzi M, Myers J. Prognostic value of end-tidal carbon dioxide during exercise testing in heart failure. Int J Cardiol. 2007;117:103–108

 Dr. Oliveira was supported by Grant BEX-3853-06-3 from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasilia, Brazil.

PII: S0002-9149(09)00926-6

doi: 10.1016/j.amjcard.2009.04.022

American Journal of Cardiology
Volume 104, Issue 4 , Pages 554-558 , 15 August 2009

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