American Journal of Cardiology
Volume 104, Issue 4 , Pages 548-553 , 15 August 2009

Correlation of Non–High-Density Lipoprotein Cholesterol and Low-Density Lipoprotein Cholesterol With Apolipoprotein B During Simvastatin + Fenofibrate Therapy in Patients With Combined Hyperlipidemia (A Subanalysis of the SAFARI Trial)

  • Scott M. Grundy, MD, PhD

      Affiliations

    • University of Texas Southwestern Medical Center, Dallas, Texas
    • Corresponding Author InformationCorresponding authors: Tel: (214) 648-2890; fax: (214) 648-4837
  • ,
  • Gloria Lena Vega, PhD

      Affiliations

    • University of Texas Southwestern Medical Center, Dallas, Texas
    • Corresponding Author InformationCorresponding authors: Tel: (214) 648-2890; fax: (214) 648-4837
  • ,
  • Joanne E. Tomassini, PhD

      Affiliations

    • Merck and Company, Incorporated, North Wales, Pennsylvania
  • ,
  • Andrew M. Tershakovec, MD, MPH

      Affiliations

    • Merck and Company, Incorporated, North Wales, Pennsylvania

Received 23 December 2008 ,Revised 8 April 2009 ,Accepted 8 April 2009.

  • Image Result

    Correlations between non-HDL cholesterol and ApoB and LDL cholesterol and ApoB in mITT population. Correlations in simvastatin 20-mg treatment group for non-HDL cholesterol and ApoB at baseline (A) an

    Correlations between non-HDL cholesterol and ApoB and LDL cholesterol and ApoB in mITT population. Correlations in simvastatin 20-mg treatment group for non-HDL cholesterol and ApoB at baseline (A) and after 12 weeks of treatment (B) and for LDL cholesterol and ApoB at baseline (C) and after 12 weeks of treatment (D). Correlations in simvastatin 20-mg plus fenofibrate 160-mg treatment group for non-HDL cholesterol and ApoB at baseline (E) and after 12 weeks of treatment (F) for LDL cholesterol and ApoB at baseline (G) and after 12 weeks of treatment (H).

 The original SAFARI trial was supported by Merck and Company, Incorporated, Whitehouse Station, New Jersey.

 Dr. Grundy's and Dr. Vega's research was supported in part by the Department of Veteran Affairs, Moss Heart Center, and Donald W. Reynolds Cardiovascular Research Center at Dallas, Texas.

 Drs. Tershakovec and Tomassini are employees of Merck and Company, Incorporated, North Wales, Pennsylvania, and own stock and stock options in the company.

PII: S0002-9149(09)00921-7

doi: 10.1016/j.amjcard.2009.04.018

American Journal of Cardiology
Volume 104, Issue 4 , Pages 548-553 , 15 August 2009