American Journal of Cardiology
Volume 103, Issue 11 , Pages 1500-1505 , 1 June 2009

Comparison of the Effects of Ramipril Versus Telmisartan on High-Sensitivity C-Reactive Protein and Endothelial Progenitor Cells After Acute Coronary Syndrome

  • Italo Porto, MD, PhD

      Affiliations

    • Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy
    • Corresponding Author InformationCorresponding author: Tel: 3906-30-15-41-87; fax: 3906-30-55-535
    • ,
  • Luca Di Vito, MD

      Affiliations

    • Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy
    • ,
  • Giovanni Luigi De Maria, MD

      Affiliations

    • Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy
    • ,
  • Ilaria Dato, MD

      Affiliations

    • Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy
    • ,
  • Alessandra Tritarelli, MSc

      Affiliations

    • Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy
    • ,
  • Antonio Maria Leone, MD, PhD

      Affiliations

    • Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy
    • ,
  • Giampaolo Niccoli, MD, PhD

      Affiliations

    • Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy
    • ,
  • Maurizio C. Capogrossi, MD

      Affiliations

    • Laboratorio di Patologia Vascolare, Istituto Dermopatico Immacolata–IRCCS, Rome, Italy
    • ,
  • Luigi Marzio Biasucci, MD, PhD

      Affiliations

    • Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy
    • ,
  • Filippo Crea, MD

      Affiliations

    • Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy

Received 4 November 2008 ,Revised 31 January 2009 ,Accepted 31 January 2009.

References 

  1. Yusuf S, Teo KK, Pogue J, Dyal L, Copland I, Schumacher H, et al. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med. 2008;358:1547–1559
  2. Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients (The Heart Outcomes Prevention Evaluation Study Investigators). N Engl J Med. 2000;342:145–153
  3. Jahn J, Hellmann I, Maass M, Giannitsis E, Dalhoff K, Katus HA. Time-dependent changes of hs-CRP serum concentration in patients with non-ST elevation acute coronary syndrome. Herz. 2004;29:795–801
  4. Bahlmann FH, de Groot K, Mueller O, Hertel B, Haller H, Fliser D. Stimulation of endothelial progenitor cells: a new putative therapeutic effect of angiotensin II receptor antagonists. Hypertension. 2005;45:526–529
  5. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med. 2003;348:593–600
  6. Moher D, Schulz KF, Altman D. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. JAMA. 2001;285:1987–1991
  7. Leuner S, Arland M, Kahl C, Jentsch-Ullrich K, Franke A, Hoffkes HG. Enumeration of CD34− positive hematopoietic progenitor cells by flow cytometry: comparison of a volumetric assay and the ISHAGE gating strategy. Bone Marrow Transplant. 1998;22:699–706
  8. Fadini GP, Baesso I, Albiero M, Sartore S, Agostini C, Avogaro A. Technical notes on endothelial progenitor cells: ways to escape from the knowledge plateau. Atherosclerosis. 2008;197:496–503
  9. Liu A, Shih WJ, Gehan E. Sample size and power determination for clustered repeated measurements. Stat Med. 2002;21:1787–1801
  10. Mitrovic V, Klein HH, Krekel N, Kreuzer J, Fichtlscherer S, Schirmer A, et al. Influence of the angiotensin converting enzyme inhibitor ramipril on high-sensitivity C-reactive protein (hs-CRP) in patients with documented atherosclerosis. Zeitschrift Kardiol. 2005;94:336–342
  11. Biasucci LM, Lombardi M, Piro M, Di Giannuario G, Liuzzo G, Crea F. Irbesartan significantly reduces C reactive protein concentrations after 1 month of treatment in unstable angina. Heart. 2005;91:670–671
  12. Yamagishi S, Nakamura K, Matsui T. Potential utility of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-modulating activity for the treatment of cardiometabolic disorders. Curr Mol Med. 2007;7:463–469
  13. Prasad K. C-reactive protein (CRP)-lowering agents. Cardiovasc Drug Rev. 2006;24:33–50
  14. Liuzzo G, Biasucci LM, Gallimore JR, Grillo RL, Rebuzzi AG, Pepys MB, et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med. 1994;331:417–424
  15. Biasucci LM, Liuzzo G, Grillo RL, Caligiuri G, Rebuzzi AG, Buffon A, et al. Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. Circulation. 1999;99:855–860
  16. Uemura H, Ishiguro H, Kubota Y. Pharmacology and new perspectives of angiotensin II receptor blocker in prostate cancer treatment. Int J Urol. 2008;15:19–26
  17. Leone AM, Rutella S, Bonanno G, Abbate A, Rebuzzi AG, Giovannini S, et al Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. Eur Heart J. 2005;26:1196–1204
  18. Massa M, Rosti V, Ferrario M, Campanelli R, Ramajoli I, Rosso R, et al Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction. Blood. 2005;105:199–206
  19. Schomig K, Busch G, Steppich B, Sepp D, Kaufmann J, Stein A, et al. Interleukin-8 is associated with circulating CD133+ progenitor cells in acute myocardial infarction. Eur Heart J. 2006;27:1032–1037
  20. George J, Goldstein E, Abashidze S, Deutsch V, Shmilovich H, Finkelstein A, et al. Circulating endothelial progenitor cells in patients with unstable angina: association with systemic inflammation. Eur Heart J. 2004;25:1003–1008
  21. Scirica BM, Morrow DA, Cannon CP, de Lemos JA, Murphy S, Sabatine MS, et al. Clinical application of C-reactive protein across the spectrum of acute coronary syndromes. Clin Chem. 2007;53:1800–1807

 This study was supported by a grant from the Fondazione Cassa di Risparmio di Roma to UNICATT Cord Blood Bank of the Catholic University of the Sacred Heart, Rome, Italy.

PII: S0002-9149(09)00534-7

doi: 10.1016/j.amjcard.2009.01.370

American Journal of Cardiology
Volume 103, Issue 11 , Pages 1500-1505 , 1 June 2009

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