American Journal of Cardiology
Volume 103, Issue 6 , Pages 862-866 , 15 March 2009

Peripheral Arterial Function in Infants and Young Children With One-Ventricle Physiology and Hypoxemia

  • Shobha Natarajan, MD

      Affiliations

    • Division of Pediatric Cardiology, University of California, San Francisco, San Francisco, California
    • Corresponding Author InformationCorresponding author: Tel: 215-590-6816; fax: 267-426-9800
    • ,
  • Christian Heiss, MD

      Affiliations

    • Division of Adult Cardiology, University of California, San Francisco, San Francisco, California
    • ,
  • Yerem Yeghiazarians, MD

      Affiliations

    • Division of Adult Cardiology, University of California, San Francisco, San Francisco, California
    • ,
  • Jeffrey R. Fineman, MD

      Affiliations

    • Division of Pediatric Critical Care, University of California, San Francisco, San Francisco, California
    • ,
  • David F. Teitel, MD

      Affiliations

    • Division of Pediatric Cardiology, University of California, San Francisco, San Francisco, California
    • ,
  • Theresa A. Tacy, MD

      Affiliations

    • Division of Pediatric Cardiology, University of California, San Francisco, San Francisco, California

Received 21 August 2008 ,Revised 13 November 2008 ,Accepted 13 November 2008.

References 

  1. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, et al Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002;39:257–265
  2. Heiss C, Sievers RE, Amabile N, Momma TY, Chen Q, Natarajan S, et al. In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound. Am J Physiol Heart Circ Physiol. 2008;294:H1086–H1093
  3. Baguet JP, Kingwell BA, Dart AL, Shaw J, Ferrier KE, Jennings GL. Analysis of the regional pulse wave velocity by Doppler: methodology and reproducibility. J Hum Hypertens. 2003;17:407–412
  4. Sandor GG, Hishitani T, Petty RE, Potts MT, Desouza A, Desouza E, et al. A novel Doppler echocardiographic method of measuring the biophysical properties of the aorta in pediatric patients. J Am Soc Echocardiogr. 2003;16:745–750
  5. Xuan YT, Whorton AR, Shearer-Poor E, Boyd J, Watkins WD. Determination of immunoreactive endothelin in medium from cultured endothelial cells and human plasma. Biochem Biophys Res Commun. 1989;164:326–332
  6. Khush KK, De Marco T, Vakharia KT, Harmon C, Fineman JR, Chatterjee K, et al. Nesiritide acutely increases pulmonary and systemic levels of nitric oxide in patients with pulmonary hypertension. J Card Fail. 2006;12:507–513
  7. Mahle WT, Todd K, Fyfe DA. Endothelial function following the Fontan operation. Am J Cardiol. 2003;91:1286–1288
  8. Akagi T, Benson LN, Green M, Ash J, Gilday DL, Williams WG, et al. Ventricular performance before and after Fontan repair for univentricular atrioventricular connection: angiographic and radionuclide assessment. J Am Coll Cardiol. 1992;20:920–926
  9. Nogaki M, Senzaki H, Masutani S, Kobayashi J, Kobayashi T, Sasaki N, et al. Ventricular energetics in Fontan circulation: evaluation with a theoretical model. Pediatr Int. 2000;42:651–657
  10. Senzaki H, Masutani S, Ishido H, Taketazu M, Kobayashi T, Sasaki N, et al. Cardiac rest and reserve function in patients with Fontan circulation. J Am Coll Cardiol. 2006;47:2528–2535
  11. Senzaki H, Masutani S, Kobayashi J, Kobayashi T, Sasaki N, Asano H, et al. Ventricular afterload and ventricular work in Fontan circulation: comparison with normal two-ventricle circulation and single-ventricle circulation with Blalock-Taussig shunts. Circulation. 2002;105:2885–2892
  12. Szabo G, Buhmann V, Graf A, Melnitschuk S, Bahrle S, Vahl CF, et al. Ventricular energetics after the Fontan operation: contractility-afterload mismatch. J Thorac Cardiovasc Surg. 2003;125:1061–1069
  13. Ferreiro CR, Chagas AC, Carvalho MH, Dantas AP, Jatene MB, Bento De Souza LC, et al. Influence of hypoxia on nitric oxide synthase activity and gene expression in children with congenital heart disease: a novel pathophysiological adaptive mechanism. Circulation. 2001;103:2272–2276
  14. Toporsian M, Govindaraju K, Nagi M, Eidelman D, Thibault G, Ward ME. Downregulation of endothelial nitric oxide synthase in rat aorta after prolonged hypoxia in vivo. Circ Res. 2000;86:671–675
  15. Han TH, Perloff JK, Liao JC. Nitric oxide metabolism in adults with cyanotic congenital heart disease. Am J Cardiol. 2007;99:691–695
  16. Oechslin E, Kiowski W, Schindler R, Bernheim A, Julius B, Brunner-La Rocca HP. Systemic endothelial dysfunction in adults with cyanotic congenital heart disease. Circulation. 2005;112:1106–1112
  17. Black SM, Fineman JR. Oxidative and nitrosative stress in pediatric pulmonary hypertension: roles of endothelin-1 and nitric oxide. Vasc Pharmacol. 2006;45:308–316
  18. Wedgwood S, Black SM. Endothelin-1 decreases endothelial NOS expression and activity through ETA receptor-mediated generation of hydrogen peroxide. Am J Physiol Lung Cell Mol Physiol. 2005;288:L480–L487
  19. Beghetti M, Black SM, Fineman JR. Endothelin-1 in congenital heart disease. Pediatr Res. 2005;57(suppl):16R–20R
  20. Ruetten H, Thiemermann C. Endothelin-1 stimulates the biosynthesis of tumour necrosis factor in macrophages: ET-receptors, signal transduction and inhibition by dexamethasone. J Physiol Pharmacol. 1997;48:675–688
  21. McEniery CM, Qasem A, Schmitt M, Avolio AP, Cockcroft JR, Wilkinson IB. Endothelin-1 regulates arterial pulse wave velocity in vivo. J Am Coll Cardiol. 2003;42:1975–1981
  22. Wilkinson IB, Qasem A, McEniery CM, Webb DJ, Avolio AP, Cockcroft JR. Nitric oxide regulates local arterial distensibility in vivo. Circulation. 2002;105:213–217
  23. Wilkinson IB, McEniery CM. Arterial stiffness, endothelial function and novel pharmacological approaches. Clin Exp Pharmacol Physiol. 2004;31:795–799
  24. de Divitiis M, Pilla C, Kattenhorn M, Donald A, Zadinello M, Wallace S, et al. Ambulatory blood pressure, left ventricular mass, and conduit artery function late after successful repair of coarctation of the aorta. J Am Coll Cardiol. 2003;41:2259–2265
  25. Mersich B, Studinger P, Lenard Z, Kadar K, Kollai M. Transposition of great arteries is associated with increased carotid artery stiffness. Hypertension. 2006;47:1197–1202
  26. Rassaf T, Kleinbongard P, Kelm M. The L-arginine nitric oxide pathway: avenue for a multiple-level approach to assess vascular function. Biol Chem. 2006;387:1347–1349

 This study was supported by Grant HL007544 from the National Institutes of Health/National Heart, Lung, and Blood Institute, Bethesda, Maryland.

PII: S0002-9149(08)02121-8

doi: 10.1016/j.amjcard.2008.11.059

American Journal of Cardiology
Volume 103, Issue 6 , Pages 862-866 , 15 March 2009

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