American Journal of Cardiology
Volume 101, Issue 9 , Pages 1247-1252 , 1 May 2008

Relation of Adult-Onset Asthma to Coronary Heart Disease and Stroke

  • Stephen J. Onufrak, PhD

      Affiliations

    • Agricultural Research Service, US Department of Agriculture, Stoneville, Mississippi
    • Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia
    • Corresponding Author InformationCorresponding author: Tel: 662-686-3437; fax: 662-686-3522.
  • ,
  • Jerome L. Abramson, PhD

      Affiliations

    • Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia
  • ,
  • Harland D. Austin, DSc

      Affiliations

    • Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia
  • ,
  • Fernando Holguin, MD, MPH

      Affiliations

    • Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia
  • ,
  • William M. McClellan, MD, MPH

      Affiliations

    • Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia
  • ,
  • L. Viola Vaccarino, MD, PhD

      Affiliations

    • Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia
    • Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia.

Received 16 November 2007 ,Revised 19 December 2007 ,Accepted 19 December 2007.

  • Image Result

    Self-reported age of asthma onset in men and women.

    Self-reported age of asthma onset in men and women.

  • Image Result

    HRs for incident CHD or stroke according to age of asthma onset and gender. Adjusted model 1 includes age, body mass index, black race, smoking status, diabetes mellitus, hypertension, education level

    HRs for incident CHD or stroke according to age of asthma onset and gender. Adjusted model 1 includes age, body mass index, black race, smoking status, diabetes mellitus, hypertension, education level, low- and high-density lipoprotein cholesterol, and physical activity; Adjusted model 2 includes model 1 covariates plus FEV1, chronic bronchitis, emphysema, and use of glucocorticoid or β-adrenergic medicines.

 This work was supported by Grant No. K24 HL077506 from the National Institutes of Health, Bethesda, Maryland. Dr. Onufrak was supported by a predoctoral fellowship from the American Heart Association, Dallas, Texas (Award Number: 0615219B).

PII: S0002-9149(08)00048-9

doi: 10.1016/j.amjcard.2007.12.024

American Journal of Cardiology
Volume 101, Issue 9 , Pages 1247-1252 , 1 May 2008