American Journal of Cardiology
Volume 99, Issue 5 , Pages 743-744 , 1 March 2007

Exercise-Induced Hypertension, Endothelial Dysfunction, and Coronary Artery Disease in a Marathon Runner

  • Radha Goel, MD

      Affiliations

    • Department of Medicine, Duke University School of Medicine, Durham, North Carolina
    • ,
  • Farhan Majeed, MD

      Affiliations

    • Department of Medicine, University of Maryland Medical Center, Baltimore, Maryland.
    • ,
  • Robert Vogel, MD

      Affiliations

    • Department of Medicine, University of Maryland Medical Center, Baltimore, Maryland.
    • ,
  • Mary C. Corretti, MD

      Affiliations

    • Department of Medicine, University of Maryland Medical Center, Baltimore, Maryland.
    • ,
  • Matthew Weir, MD

      Affiliations

    • Department of Medicine, University of Maryland Medical Center, Baltimore, Maryland.
    • ,
  • Charles Mangano, RDMS

      Affiliations

    • Department of Medicine, University of Maryland Medical Center, Baltimore, Maryland.
    • ,
  • Charles White, MD

      Affiliations

    • Department of Radiology, University of Maryland Medical Center, Baltimore, Maryland.
    • ,
  • Gary D. Plotnick, MD

      Affiliations

    • Department of Medicine, University of Maryland Medical Center, Baltimore, Maryland.
    • ,
  • Michael Miller, MD

      Affiliations

    • Department of Medicine, University of Maryland Medical Center, Baltimore, Maryland.
    • Department of Epidemiology and Preventive Medicine, University of Maryland Medical Center, Baltimore, Maryland.
    • Corresponding Author InformationCorresponding author: Tel: 410-328-6299; fax: 410-328-4382.

Received 29 August 2006 ,Revised 19 September 2006 ,Accepted 19 September 2006.

References 

  1. Jurva JW, Phillips SA, Syed AQ, Syed AY, Pitt S, Weaver A, et al. The effect of exertional hypertension evoked by weight lifting on vascular endothelial function. J Am Coll Cardiol. 2006;48:588–589
  2. Corretti M, Plotnick GD, Vogel RA. Effect of treadmill exercise on flow-mediated brachial artery vasoactivity. J Am Coll Cardiol. 1996;27:130A
  3. Fletcher GF, Balady GJ, Amsterdam EA, Chaitman B, Eckel R, Fleg J, et al Exercise standards for testing and training: a statement for healthcare professionals from the American Heart Association. Circulation. 2001;104:1694–1740
  4. DeSouza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka H, et al. Regular aerobic exercise prevents and restores age-related decline in endothelial-dependent vasodilation in healthy men. Circulation. 2000;102:1351–1357
  5. Mastaloudis A, Leonard SW, Traber MG. Oxidative stress in athletes during extreme endurance exercise. Free Radical Biol Med. 2001;31:911–922
  6. Goto C, Higashi Y, Kimura M, Noma K, Hara K, Nakagawa K, et al. Effect of different intensities of exercise on endothelium-dependent vasodilation in humans (role of endothelium-dependent nitric oxide and oxidative stress). Circulation. 2003;108:530–535
  7. Plotnick GD, Corretti MC, Vogel RA. Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. JAMA. 1997;278:1682–1686
  8. Inoue N, Ramasamy S, Fukai T, Nerem RM, Harrison DG. Shear stress modulates expression of Cu/Zn superoxide dismutase in human aortic endothelial cells. Circ Res. 1996;79:32–37
  9. Allison TG, Cordeiro MAS, Miller TD, Daida H, Squires RW, Gau GT. Prognostic significance of exercise-induced systemic hypertension in healthy subjects. Am J Cardiol. 1999;83:371–375

PII: S0002-9149(06)02315-0

doi: 10.1016/j.amjcard.2006.09.127

American Journal of Cardiology
Volume 99, Issue 5 , Pages 743-744 , 1 March 2007

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