American Journal of Cardiology
Volume 99, Issue 2 , Pages 186-188 , 15 January 2007

Comparison of Effectiveness of Enoxaparin Versus Unfractionated Heparin to Reduce Silent and Clinically Apparent Acute Myocardial Infarction in Patients Presenting With Non–ST-Segment Elevation Acute Coronary Syndrome

  • Sanjit Jolly, MD

      Affiliations

    • Terrence Donnelly Heart Centre, Division of Cardiology, St. Michaelx2019;s Hospital, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Mary Tan

      Affiliations

    • Canadian Heart Research Centre, Division of Cardiology, St. Michaelx2019;s Hospital, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Aurora Mendelsohn

      Affiliations

    • Canadian Heart Research Centre, Division of Cardiology, St. Michaelx2019;s Hospital, University of Toronto, Toronto, Ontario, Canada
    • ,
  • David Fitchett, MD

      Affiliations

    • Canadian Heart Research Centre, Division of Cardiology, St. Michaelx2019;s Hospital, University of Toronto, Toronto, Ontario, Canada
    • Terrence Donnelly Heart Centre, Division of Cardiology, St. Michaelx2019;s Hospital, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Paul W. Armstrong, MD

      Affiliations

    • Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada.
    • ,
  • Anatoly Langer, MD

      Affiliations

    • Canadian Heart Research Centre, Division of Cardiology, St. Michaelx2019;s Hospital, University of Toronto, Toronto, Ontario, Canada
    • Terrence Donnelly Heart Centre, Division of Cardiology, St. Michaelx2019;s Hospital, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Shaun G. Goodman, MD

      Affiliations

    • Canadian Heart Research Centre, Division of Cardiology, St. Michaelx2019;s Hospital, University of Toronto, Toronto, Ontario, Canada
    • Terrence Donnelly Heart Centre, Division of Cardiology, St. Michaelx2019;s Hospital, University of Toronto, Toronto, Ontario, Canada
    • Corresponding Author InformationCorresponding author: Tel: 416-864-5722; fax: 416-864-5407.

Received 15 February 2006 ,Revised 25 July 2006 ,Accepted 25 July 2006.

References 

  1. Cohen M, Demers C, Gurfinkel EP, Turpie AG, Fromell GJ, Goodman S, et al. A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease (Efficacy and Safety of Subcutaneous Enoxaparin in Non–Q-Wave Coronary Events Study Group). N Engl J Med. 1997;337:447–452
  2. Antman EM, Cohen M, Radley D, McCabe C, Rush J, Premmereur J, et al. Assessment of the treatment effect of enoxaparin for unstable angina/non–Q-wave myocardial infarction: TIMI 11B-ESSENCE meta-analysis. Circulation. 1999;100:1602–1608
  3. Goodman SG, Barr A, Sobtchouk A, Cohen M, Fromell GJ, Laperriere L, et al. Low molecular weight heparin decreases rebound ischemia in unstable angina or non–Q wave myocardial infarction: the Canadian ESSENCE ST segment monitoring substudy. J Am Coll Cardiol. 2000;36:1507–1513
  4. Antman EM, Cohen M, McCabe C, Goodman SG, Murphy SA, Braunwald E TIMI 11B and ESSENCE Investigators. Enoxaparin is superior to unfractionated heparin for preventing clinical events at one year follow-up of TIMI 11B and ESSENCE. Eur Heart J. 2002;23:308–314
  5. Goodman SG, Fitchett D, Armstrong PW, Tan M, Langer A Integrilin and Enoxaparin Randomized Assessment of Acute Coronary Syndrome Treatment (INTERACT) Trial Investigators. Randomized evaluation of the safety and efficacy of enoxaparin versus unfractionated heparin in high risk patients with non–ST-segment elevation acute coronary syndromes receiving the glycoprotein IIb/IIIa inhibitor eptifibatide. Circulation. 2003;107:238–244
  6. Hindman NB, Shocken DD, Widmann M, Anderson WD, White RD, Leggett S, et al. Evaluation of a QRS scoring system for estimating myocardial infarct size (Specificity and method of application of the complete system). Am J Cardiol. 1985;55:1485–1490
  7. Bergovec M, Prpic H, Mihatov S, Zigman M, Vukosavic D, Birtic K, et al. The value of the QRS scoring system in assessing regional and global left ventricular ejection fraction early after myocardial infarction. Eur Heart J. 1993;14:1102–1109
  8. Palmeri ST, Harrison DG, Cobb FR, Morris KG, Harrell FE, Ideker RE, et al. A QRS scoring system for assessing left ventricular function after myocardial infarction. N Engl J Med. 1982;306:4–9
  9. Jones MG, Anderson KM, Wilson PWF, Kannel WB, Wagner NB, Wagner GS. Prognostic use of a QRS scoring system after hospital discharge for initial acute myocardial infarction in the Framingham cohort. Am J Cardiol. 1990;66:546–550
  10. Bounhous EP, Califf RM, Harrell FE, Hinohara T, Mark DB, Ideker RE, et al. Prognostic value of the simplified Selvester QRS score in patients with coronary artery disease. J Am Coll Cardiol. 1988;11:35–41
  11. RITA Trial Participants. Coronary angioplasty versus coronary bypass surgery: the Randomized Intervention Treatment of Angina (RITA) trial. Lancet. 1993;341:573–580
  12. Chaitman BR, Rosen AD, Williams DO, Bourassa MG, Aguirre FV, Pitt B, et al Myocardial infarction and cardiac mortality in the Bypass Angioplasty Revascularization Investigation (BARI) randomized trial. Circulation. 1997;96:2162–2170

 The ESSENCE study and ESSENCE ECG substudy were sponsored by Aventis Pharma, USA. The INTERACT study was sponsored by the Canadian Heart Research Centre, Toronto, Ontario, Canada; Key Pharmaceuticals, Division of Schering Canada, Inc., Kirkland, Quebec, Canada; and Millienium Pharmaceuticals, Inc., Cambridge, Massachusetts.

PII: S0002-9149(06)01996-5

doi: 10.1016/j.amjcard.2006.07.078

American Journal of Cardiology
Volume 99, Issue 2 , Pages 186-188 , 15 January 2007

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