American Journal of Cardiology
Volume 97, Issue 9 , Pages 1274-1276 , 1 May 2006

An Insulin-Like Growth Factor-I Promoter Polymorphism Is Associated With Increased Mortality in Subjects With Myocardial Infarction in an Elderly Caucasian Population

  • Mojgan Yazdanpanah, MD, DSc

      Affiliations

    • Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    • ,
  • Ingrid Rietveld, MD

      Affiliations

    • Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    • Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    • ,
  • Joop A.M.J.L. Janssen, MD, PhD

      Affiliations

    • Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    • ,
  • Omer T. Njajou, PhD

      Affiliations

    • Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    • ,
  • Albert Hofman, MD, PhD

      Affiliations

    • Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    • ,
  • Theo Stijnen, PhD

      Affiliations

    • Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    • ,
  • Huibert A.P. Pols, MD, PhD

      Affiliations

    • Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    • Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    • ,
  • Steven W.J. Lamberts, MD, PhD

      Affiliations

    • Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    • ,
  • Jacqueline C.M. Witteman, PhD

      Affiliations

    • Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    • ,
  • Cornelia M. van Duijn, PhD

      Affiliations

    • Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    • Corresponding Author InformationCorresponding author: Tel: 31-10-408-7394; fax: 31-10-408-9406.

Received 23 September 2005 ,Revised 14 November 2005 ,Accepted 14 November 2005.

References 

  1. Ren J , Samson WK , Sowers JR . Insulin-like growth factor I as a cardiac hormone (physiological and pathophysiological implications in heart disease) . J Mol Cell Cardiol . 1999;31:2049–2061
  2. Conti E, Andreotti F, Sciahbasi A, Riccardi P, Marra G, Menini E, et al. Markedly reduced insulin-like growth factor-1 in the acute phase of myocardial infarction . J Am Coll Cardiol . 2001;38:26–32
  3. Hong Y , Pedersen NL , Brismar K , Hall K , de Faire U . Quantitative genetic analyses of insulin-like growth factor I (IGF-I), IGF-binding protein-1, and insulin levels in middle-aged and elderly twins . J Clin Endocrinol Metab . 1996;81:1791–1797
  4. Vaessen N, Heutink P, Janssen JA, Witteman JC, Testers L, Hofman A, et al. A polymorphism in the gene for IGF-I (functional properties and risk for type 2 diabetes and myocardial infarction) . Diabetes . 2001;50:637–642
  5. Rietveld I, Janssen JA, van Rossum EF, Houwing-Duistermaat JJ, Rivadeneria F, Hofman A, et al. A polymorphic CA repeat in the IGF-I gene is associated with gender-specific differences in body height, but has no effect on the secular trend in body height . Clin Endocrinol . 2004;61:195–203
  6. Bleumink GS, Rietveld I, Janssen JAMJL, van Rossum EFC, Deckers JW, Hofman A, et al. Insulin-like growth factor-I gene polymorphism and risk of heart failure (the Rotterdam Study) . Am J Cardiol . 2004;94:384–386
  7. Li B, Setoguchi M, Wang X, Andreoli AM, Leri A, Malhotra A, et al. Insulin-like growth factor-1 attenuates the detrimental impact of nonocclusive coronary artery constriction on the heart . Circ Res . 1999;84:1007–1019

 The Rotterdam Study is supported by the Erasmus Medical Center and Erasmus University, Rotterdam; Organization for Scientific Research, The Netherlands Organization for Health Research and Development, the Research Institute for Diseases in the Elderly, the Ministry of Education, Culture and Science, the Ministry of Health, Welfare and Sports, and the European Commission (DG XII), The Hague; the Municipality of Rotterdam, Rotterdam; and the Centre for Medical Systems Biology, Leiden, The Netherlands.

PII: S0002-9149(06)00175-5

doi: 10.1016/j.amjcard.2005.11.069

American Journal of Cardiology
Volume 97, Issue 9 , Pages 1274-1276 , 1 May 2006

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