American Journal of Cardiology
Volume 96, Issue 11 , Pages 1491-1493, 1 December 2005

Effect of Statin Use in Patients With Acute Coronary Syndromes and a Serum Low-Density Lipoprotein ≤80 mg/dl

  • Thomas T. Tsai, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
    • Corresponding Author InformationCorresponding author: Tel: 734-998-4967; fax: 734-998-9939.
  • ,
  • Brahmajee K. Nallamothu, MD, MPH

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
    • Health Services Research and Development Center of Excellence, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan.
  • ,
  • Debabrata Mukherjee, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
  • ,
  • Melvyn Rubenfire, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
  • ,
  • Jianming Fang, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
  • ,
  • Paul Chan, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
    • Health Services Research and Development Center of Excellence, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan.
  • ,
  • Eva Kline-Rogers, RN

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
  • ,
  • Amisha Patel, BS

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
  • ,
  • David F. Armstrong, BS

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
  • ,
  • Kim A. Eagle, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.
  • ,
  • A.D. Goldberg, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan.

Received 13 April 2005; received in revised form 8 July 2005; accepted 8 July 2005. published online 13 October 2005.

We identified 155 patients who were admitted with an acute coronary syndrome and a low-density lipoprotein cholesterol level ≤80 mg/dl and were not on statin therapy at hospital admission. The relation between statin therapy at discharge and clinical outcome was evaluated in these patients. Compared with patients who were not discharged on statins, those who were had a lower incidence of death, reinfarction, or stroke at 6 months (29.0% vs 9.5%, p = 0.005). These results suggest that patients who have an acute coronary syndrome and a low-density lipoprotein cholesterol level ≤80 mg/dl in the absence of statin therapy may benefit from such therapy at discharge.

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 Dr. Tsai is supported by training grant 5T32HL007853-08 and Dr. Nallamothu is supported by K12 grant RR017607-01 from the National Institutes of Health, Bethesda, Maryland.

PII: S0002-9149(05)01452-9

doi:10.1016/j.amjcard.2005.07.069

American Journal of Cardiology
Volume 96, Issue 11 , Pages 1491-1493, 1 December 2005