American Journal of Cardiology
Volume 96, Issue 5 , Pages 611-616 , 1 September 2005

Effect of Statin Use Within the First 24 Hours of Admission for Acute Myocardial Infarction on Early Morbidity and Mortality†

  • Gregg C. Fonarow, MD

      Affiliations

    • Ahmanson-UCLA Cardiomyopathy Center, UCLA Division of Cardiology
    • Corresponding Author InformationCorresponding author: Tel.: 310-206-9112; fax: 310-206-9111.
    • ,
  • R. Scott Wright, MD

      Affiliations

    • Mayo Clinic, Rochester, Minnesota
    • ,
  • Frederick A. Spencer, MD

      Affiliations

    • University of Massachusetts, Worcester, Massachusetts
    • ,
  • Paul D. Fredrick, MPH, MBA

      Affiliations

    • Ovation Research Group, Seattle, Washington
    • ,
  • Wei Dong, MD, PhD

      Affiliations

    • Medical Affairs, Genentech, Inc., South San Francisco, California.
    • ,
  • Nathan Every, MD, PhD

      Affiliations

    • University of Washington, Seattle, Washington
    • ,
  • William J. French, MD

      Affiliations

    • Harbor-UCLA Medical Center, Los Angeles, California
    • ,
  • National Registry of Myocardial Infarction 4 Investigators

Received 23 March 2005 ,Revised 21 April 2005 ,Accepted 21 April 2005.

References 

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  2. Lefer AM , Campbell B , Shin YK , Scalia R , Hayward R , Lefer DJ . Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts . Circulation . 1999;100:178–184
  3. Every NR , Frederick PD , Robinson M , Sugarman J , Bowlby L , Barron HV . A comparison of the national registry of myocardial infarction 2 with the cooperative cardiovascular project . J Am Coll Cardiol . 1999;33:1886–1894
  4. Rubin DB . Estimating causal effects from large data sets using propensity scores . Ann Intern Med . 1997;127:757–763
  5. Di Napoli P, Antonio Taccardi A, Grilli A, Spina R, Felaco M, Barsotti A, et al. Simvastatin reduces reperfusion injury by modulating nitric oxide synthase expression (an ex vivo study in isolated working rat hearts) . Cardiovasc Res . 2001;51:283–293
  6. Laufs U , La Fata V , Plutzky J , Liao J . Upregulation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors . Circulation . 1998;97:1129–1135
  7. Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer DJ, et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals . Nat Med . 2000;6:1–7
  8. Hayashidani S, Tsutsui H, Shiomi T, Suematsu N, Kinugawa S, Ide T, et al. Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction . Circulation . 2002;105:868–873
  9. Kwak B , Mulhaupt F , Myit S , Mach F . Statins as a newly recognized type of immunomodulator . Nat Med . 2000;6:1399–1402

 The National Registry of Myocardial Infarction 4 is supported by Genentech, Inc., South San Francisco, California.

PII: S0002-9149(05)00925-2

doi: 10.1016/j.amjcard.2005.04.029

American Journal of Cardiology
Volume 96, Issue 5 , Pages 611-616 , 1 September 2005

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